CD62L ligand Inhibitors
CD62L ligand inhibitors are chemical compounds designed to specifically interfere with the interaction between CD62L, also known as L-selectin, and its ligands. CD62L is a cell adhesion molecule expressed on the surface of leukocytes, and it plays a pivotal role in mediating the adhesion of these immune cells to endothelial cells, particularly in processes such as leukocyte trafficking and homing to lymphoid tissues. The binding of CD62L to its ligands, including glycoproteins like GlyCAM-1, MadCAM-1, and CD34, facilitates the rolling and adhesion of leukocytes along blood vessel walls, an important step in immune surveillance and response to inflammation. Inhibitors targeting CD62L ligands are aimed at blocking this specific molecular interaction, thus modulating the cellular adhesion processes governed by CD62L.
The design of CD62L ligand inhibitors requires a detailed understanding of the molecular interface between CD62L and its ligands. These inhibitors can be small molecules, peptides, or biologics engineered to either block the ligand-binding site on CD62L or prevent ligands from interacting with the receptor. Key challenges in the development of these inhibitors include ensuring high specificity for the CD62L-ligand interaction without affecting other selectins or adhesion molecules. Additionally, factors such as binding affinity, solubility, and stability must be optimized to ensure effective inhibition of the CD62L-ligand interaction under physiological conditions. By disrupting this interaction, CD62L ligand inhibitors are valuable tools for exploring the role of cell adhesion in immune cell trafficking, signaling, and tissue infiltration, contributing to a deeper understanding of how leukocytes migrate and respond to various biological signals.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin may downregulate CD62L ligand expression by inhibiting cyclooxygenase-1 (COX-1), potentially reducing prostaglandin E2 levels, a mediator that could increase the expression of adhesion molecules on endothelial cells during inflammation. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Hydrocortisone could suppress CD62L ligand expression through activation of glucocorticoid receptors leading to a decrease in cytokine production, which are key in the upregulation of endothelial adhesion molecules during immune responses. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin may decrease CD62L ligand expression by suppressing the activity of kinases involved in the activation of inflammatory transcription factors, which are crucial for the transcription of endothelial adhesion molecules. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $53.00 $88.00 | 6 | |
Ibuprofen could reduce CD62L ligand expression by blocking COX enzymes, leading to a decrease in the synthesis of inflammatory mediators that can enhance the expression of adhesion molecules on the endothelial surface. | ||||||
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $32.00 $86.00 $150.00 | 3 | |
Sulindac may decrease CD62L ligand expression by inhibiting the COX pathway, leading to a reduced production of inflammatory mediators that can promote the upregulation of endothelial adhesion molecules. | ||||||
Vioxx | 162011-90-7 | sc-208486 | 100 mg | $190.00 | 3 | |
Vioxx could decrease CD62L ligand expression by selectively inhibiting COX-2, reducing the production of pro-inflammatory prostaglandins that can upregulate adhesion molecules on endothelial cells. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate could inhibit CD62L ligand expression by attenuating the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a key transcription factor in the transcriptional activation of endothelial adhesion molecules. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $61.00 $77.00 $128.00 $209.00 | 8 | |
Sulfasalazine might reduce CD62L ligand expression by suppressing the synthesis of immune mediators that can stimulate the expression of adhesion molecules on the endothelial cell surface. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate could inhibit CD62L ligand expression by reducing folate metabolism, leading to diminished purine synthesis, which is necessary for the proliferation of cells that express adhesion molecules. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid could downregulate CD62L ligand expression by binding to retinoic acid receptors, which may repress genes responsible for the expression of endothelial adhesion molecules. | ||||||