CCS Inhibitors

CCS Inhibitors includes various compounds that can potentially suppress or modulate the activity of CCS, primarily by affecting copper homeostasis and utilization. This class includes copper chelators like Tetrathiomolybdate, Disulfiram, D-Penicillamine, Bathocuproine, Trientine, and Clioquinol, which directly sequester copper, reducing its availability for binding and activation by CCS. Zinc Acetate and Molybdate are included due to their competitive inhibition with copper, which can indirectly affect CCS function. Inhibitors of ceruloplasmin might also impact copper transport and availability for CCS. EDTA, a broad-spectrum chelator, could potentially sequester copper, while Neocuproine and Quercetin, with their metal-chelating properties, can also influence copper homeostasis and CCS activity.