CCDC130 Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that can reduce the activity of the mTORC1 complex. CCDC130 is involved in the regulation of ciliogenesis and autophagy, which are processes that can be negatively regulated by mTOR signaling, leading to its inhibition. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that impedes the PI3K/Akt pathway. Since the PI3K/Akt pathway is upstream of mTORC1, which affects ciliogenesis, inhibiting PI3K can lead to a reduction in CCDC130 activity by impeding the pathway that regulates its function. | ||||||
rac Perhexiline Maleate | 6724-53-4 | sc-460183 | 10 mg | $188.00 | ||
Perhexiline inhibits carnitine palmitoyltransferase-1 (CPT1), which is crucial for mitochondrial beta-oxidation of fatty acids. By altering mitochondrial function, this can affect ciliogenesis and thereby indirectly inhibit CCDC130's function in this process. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose acts as a glycolysis inhibitor by impeding hexokinase, which can lead to energy deprivation in the cell. This energy stress can negatively affect the assembly and function of cilia, indirectly inhibiting CCDC130's role in ciliogenesis. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is an inhibitor of the V-ATPase proton pump, leading to disruption of autophagic processes. Given that CCDC130 is implicated in autophagy, its function can be indirectly inhibited by bafilomycin A1 through the impairment of autophagy. | ||||||
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
3-Methyladenine is an autophagy inhibitor that acts by inhibiting PI3K class III. Since CCDC130 has a role in autophagy, its functional activity can be inhibited by 3-methyladenine through the suppression of autophagic vesicle formation. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine is a compound that inhibits autophagy by preventing the acidification of lysosomes. This can lead to reduced degradation of autophagosomes, thereby indirectly inhibiting CCDC130's role in the autophagic process. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and can disrupt microtubule dynamics necessary for ciliogenesis. This stabilization can impede the correct formation of cilia, indirectly inhibiting the functional role of CCDC130 in this cellular process. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule depolymerizing agent that can disrupt microtubule organization, which is essential for ciliogenesis. Its action can lead to the inhibition of CCDC130 by preventing the proper assembly of cilia, where CCDC130 is involved. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C is a DNA crosslinker that can induce DNA damage responses and cell cycle arrest. Since ciliogenesis is closely tied to the cell cycle, mitomycin C can indirectly inhibit CCDC130 activity by disrupting the cell cycle-dependent ciliogenesis. | ||||||