casein kinase IIα′ Activators
The first group of casein kinase IIα (CK2α) activators includes TBB, Quercetin, Apigenin, Ellagic Acid, Emodin, and Resveratrol. These compounds inhibit CK2α by binding to its ATP-binding site. This action results in a reduction of its kinase activity. Notably, this inhibitory action can indirectly enhance CK2α activity through a feedback mechanism. The body recognizes that CK2α activity is compromised due to the presence of these inhibitors and responds by upregulating the enzyme's activity to compensate. This group of compounds, therefore, indirectly enhances CK2α activity by triggering this compensatory response.
The second group of CK2α activators includes Silibinin, Genistein, EGCG, Curcumin, Fisetin, and Baicalein. Similar to the first group, these compounds inhibit CK2α by competing with ATP to bind to the ATP-binding site of the enzyme. The inhibitory action of these compounds can lead to an upregulation of CK2α activity as a response mechanism. When the body senses that CK2α activity is reduced due to the presence of these inhibitors, it responds by increasing the enzyme's activity. Thus, these compounds indirectly enhance CK2α activity by initiating this compensatory response.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
TBB | 17374-26-4 | sc-202830 sc-202830A sc-202830C sc-202830B sc-202830D | 10 mg 25 mg 50 mg 100 mg 250 mg | $245.00 $370.00 $454.00 $760.00 $1817.00 | 17 | |
TBB is a specific inhibitor of casein kinase IIα (CK2α). It works by binding to the ATP-binding site of the enzyme, reducing its kinase activity. This inhibition can lead to an upregulation of CK2α activity as a feedback mechanism. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that acts as a CK2α inhibitor by competing with ATP to bind to the ATP-binding pocket of CK2α. This competitive inhibition can lead to an increased activity of CK2α through a feedback mechanism. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is another flavonoid that inhibits CK2α by binding to its ATP-binding site. This inhibitory action can indirectly enhance CK2α activity through a feedback mechanism. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic acid is a polyphenol that inhibits CK2α by binding to its ATP-binding site. This inhibitory action can lead to an upregulation of CK2α activity as a response mechanism. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
Emodin is an anthraquinone that acts as a CK2α inhibitor by competing with ATP to bind to the ATP-binding site of CK2α. This can lead to an increased CK2α activity through a feedback mechanism. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a stilbenoid that inhibits CK2α by binding to its ATP-binding site. This can lead to an upregulation of CK2α activity as a response mechanism. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $55.00 $114.00 $206.00 $714.00 | 6 | |
Silibinin is a flavonolignan that acts as a CK2α inhibitor. It competes with ATP to bind to the ATP-binding site of CK2α, which can lead to an increased CK2α activity through a feedback mechanism. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone that inhibits CK2α by binding to its ATP-binding site. This inhibitory action can indirectly enhance CK2α activity through a feedback mechanism. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin that acts as a CK2α inhibitor by competing with ATP to bind to the ATP-binding site of CK2α. This competition can lead to an upregulation of CK2α activity as a response mechanism. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a curcuminoid that inhibits CK2α by binding to its ATP-binding site. This inhibitory action can indirectly enhance CK2α activity through a feedback mechanism. | ||||||