Carcinoma marker Activators
Carcinoma marker activators encompass a diverse array of chemical compounds that interact with cellular signaling pathways, ultimately leading to the enhancement of the carcinoma marker's functional activity. For instance, Forskolin, by elevating cAMP levels, can indirectly enhance the activation of the carcinoma marker by catalyzing the activity of PKA, which is known to phosphorylate a variety of proteins within the cell. Similarly, PMA, by activating PKC, can lead to the phosphorylation of substrates that may include the carcinoma marker, thus enhancing its activity.
Compounds such as EGF influence receptor tyrosine kinase pathways, leading to a cascade of kinase activations that intersect with the carcinoma marker's functional regulation. Anisomycin, by inducing stress-activated kinases, and Ionomycin, by raising intracellular calcium levels, can both modulate signaling pathways that enhance the carcinoma marker's activity. Inhibitors like Okadaic Acid and Calyculin A can prevent the dephosphorylation of proteins, resulting in sustained activation of the carcinoma marker. U73122's inhibition of phospholipase C can affect downstream effectors that may enhance the carcinoma marker's function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, which increases levels of cyclic AMP (cAMP) in cells. Elevated cAMP can enhance protein kinase A (PKA) activity, which may then phosphorylate the carcinoma marker, enhancing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in numerous signaling pathways. PKC can phosphorylate a wide range of substrates, potentially including the carcinoma marker, resulting in its enhanced activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases (SAPKs). These kinases could phosphorylate the carcinoma marker, leading to its functional enhancement. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, which can activate calcium-dependent enzymes and signaling pathways that may enhance the activity of the carcinoma marker. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
db-cAMP is a cell-permeable analog of cAMP. It activates PKA directly, enhancing the phosphorylation of various proteins, possibly including the carcinoma marker, thus enhancing its function. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels in the cell. This might result in enhanced phosphorylation and activation of the carcinoma marker. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Similar to okadaic acid, calyculin A inhibits protein phosphatases 1 and 2A, which could enhance the phosphorylation state of the carcinoma marker, potentially leading to its activation. | ||||||