CaMKII Substrates
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Items 11 to 16 of 16 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
CREB1 (Ser 133) | sc-24520 | 0.5 mg/0.1 ml | $95.00 | 2 | ||
CREB-1 (Ser 133) functions as a critical transcription factor, modulating gene expression in response to various signaling pathways. Phosphorylation at Ser 133 enhances its binding to the CRE (cAMP response element), facilitating the recruitment of coactivators and chromatin remodeling complexes. This modification is pivotal in regulating neuronal survival and differentiation, with distinct kinetics influenced by calcium and cAMP levels, underscoring its role in cellular adaptation and memory formation. | ||||||
Op18 (Ser 63) | sc-24524 | 0.5 mg/0.1 ml | $95.00 | |||
Op18 (Ser 63) acts as a pivotal modulator within the calcium/calmodulin-dependent protein kinase II (CaMKII) pathway. Its phosphorylation at Ser 63 enhances enzyme activity, promoting autophosphorylation and facilitating calcium signaling. This modification influences substrate specificity and alters reaction kinetics, allowing for rapid responses to calcium fluctuations. The unique conformational changes induced by this phosphorylation are crucial for synaptic plasticity and neuronal signaling dynamics. | ||||||
WT (Ser 393) | sc-24525 | 0.5 mg/0.1 ml | $95.00 | |||
WT (Ser 393) serves as a critical regulator in the CaMKII signaling cascade, where its phosphorylation at Ser 393 significantly alters the enzyme's conformation and activity. This modification enhances the binding affinity for calcium/calmodulin, leading to increased autophosphorylation rates. The distinct structural rearrangements promote specific interactions with downstream substrates, fine-tuning the signaling pathways involved in cellular responses to calcium levels and influencing overall cellular dynamics. | ||||||
Adducin (Ser 662) | sc-24527 | 0.5 mg/0.1 ml | $95.00 | |||
Adducin (Ser 662) plays a pivotal role in modulating the activity of CaMKII through its phosphorylation at Ser 662, which induces conformational changes that enhance enzyme stability. This modification facilitates the enzyme's interaction with various scaffolding proteins, promoting localized signaling. The altered kinetics of substrate phosphorylation contribute to the precision of calcium-dependent signaling, impacting cellular processes such as synaptic plasticity and muscle contraction. | ||||||
Na+/K+-ATPase α (Ser 943) | sc-24529 | 0.5 mg/0.1 ml | $95.00 | |||
Na+/K+-ATPase α (Ser 943) serves as a critical regulator of cellular ion homeostasis, with its phosphorylation at Ser 943 influencing its interaction with calmodulin. This modification enhances the enzyme's affinity for ATP, thereby accelerating its reaction kinetics. The altered binding dynamics facilitate efficient ion transport across the membrane, impacting cellular excitability and signaling pathways. This interplay is essential for maintaining electrochemical gradients vital for various physiological functions. | ||||||
IRS-1 (Ser 270) | sc-24558 | 0.5 mg/0.1 ml | $95.00 | |||
IRS-1 (Ser 270) plays a pivotal role in cellular signaling by modulating the activity of CaMKII, a key kinase involved in calcium-dependent pathways. Phosphorylation at Ser 270 enhances the binding affinity of IRS-1 to various signaling proteins, promoting the formation of multiprotein complexes. This modification influences downstream signaling cascades, affecting metabolic processes and cellular responses to stimuli, thereby contributing to the intricate regulation of cellular functions. | ||||||