Calponin 3 Inhibitors
The class of Calponin 3 inhibitors encompasses a diverse range of compounds meticulously designed to modulate the intricate pathways associated with Calponin 3 activity. These inhibitors act through various mechanisms, directly targeting Calponin 3 or indirectly influencing its function through shared signaling cascades. Notably, selective inhibitors like CK-666 and SMIFH2 exert their effects by directly inhibiting the actin cytoskeleton dynamics, disrupting the pathways where Calponin 3 interacts with actin filaments. By doing so, these inhibitors interfere with the intricate regulation of actin polymerization and depolymerization, thus indirectly impacting Calponin 3 activity.
Furthermore, compounds like ML-7 and ML-9 take a direct approach by inhibiting myosin light chain kinase (MLCK), a key regulator of actin-myosin interactions. Through this direct modulation, they disrupt the downstream signaling pathways that involve Calponin 3, affecting its role in actin filament dynamics. Additionally, other inhibitors such as Y-27632 target the Rho-associated protein kinase (ROCK) pathway, indirectly influencing Calponin 3 by disrupting the actin cytoskeleton organization regulated by this pathway. The class also includes selective inhibitors of the extracellular signal-regulated kinase (ERK) pathway, such as U0126 and PD0325901, which can impact Calponin 3 through their effects on downstream signaling components involved in actin dynamics. In conclusion, the Calponin 3 inhibitors present a comprehensive toolkit for modulating its activity, offering avenues for targeted interventions in cellular processes intricately connected to actin cytoskeleton dynamics.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin inhibits Calponin 3 directly by disrupting actin-myosin interactions. It binds to myosin ATPase, preventing the myosin-ADP-phosphate complex formation, thus inhibiting the actin-binding capacity of myosin. This direct inhibition leads to the modulation of Calponin 3, affecting its ability to regulate actin dynamics and cellular processes dependent on actomyosin interactions. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits Calponin 3 indirectly by targeting Rho-associated protein kinase (ROCK). By inhibiting ROCK, Y-27632 interferes with the RhoA/ROCK signaling pathway, which plays a role in actin cytoskeleton regulation. The indirect modulation of Calponin 3 by Y-27632 involves the disruption of downstream signaling events that impact actin dynamics and cellular processes regulated by Calponin 3. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 inhibits Calponin 3 indirectly by targeting myosin light chain kinase (MLCK). By inhibiting MLCK, ML-7 disrupts the phosphorylation of myosin light chain, affecting actomyosin interactions. This indirect modulation leads to alterations in actin dynamics and cellular processes regulated by Calponin 3. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits Calponin 3 indirectly by acting as a potent protein phosphatase inhibitor. By preventing the dephosphorylation of proteins, including myosin, Calyculin A disrupts actin-myosin interactions. The indirect modulation of Calponin 3 by Calyculin A involves alterations in phosphorylation events that impact actin dynamics and cellular processes regulated by Calponin 3. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D inhibits Calponin 3 indirectly by disrupting actin polymerization. By binding to the growing ends of actin filaments, Cytochalasin D prevents further polymerization, affecting actin dynamics. The indirect modulation of Calponin 3 by Cytochalasin D involves alterations in the actin cytoskeleton, impacting cellular processes regulated by Calponin 3 through its interactions with actin filaments. | ||||||
H-1152 dihydrochloride | 451462-58-1 | sc-203592 sc-203592A | 1 mg 5 mg | $104.00 $364.00 | 7 | |
H-1152 inhibits Calponin 3 indirectly by targeting Rho-associated protein kinase (ROCK). Similar to Y-27632, H-1152 disrupts the RhoA/ROCK signaling pathway, influencing actin cytoskeleton dynamics. The indirect modulation of Calponin 3 by H-1152 involves interference with downstream signaling events that impact actin dynamics and cellular processes regulated by Calponin 3. | ||||||
Latrunculin B | 76343-94-7 | sc-203318 | 1 mg | $240.00 | 29 | |
Latrunculin B inhibits Calponin 3 indirectly by disrupting actin polymerization. It sequesters monomeric actin, preventing its incorporation into growing filaments and thereby affecting actin dynamics. The indirect modulation of Calponin 3 by Latrunculin B involves alterations in the actin cytoskeleton, impacting cellular processes regulated by Calponin 3 through its interactions with actin filaments. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Jasplakinolide inhibits Calponin 3 indirectly by stabilizing F-actin. By binding to actin filaments, Jasplakinolide prevents depolymerization, affecting actin dynamics. The indirect modulation of Calponin 3 by Jasplakinolide involves alterations in the actin cytoskeleton, impacting cellular processes regulated by Calponin 3 through its interactions with stabilized actin filaments. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 inhibits Calponin 3 indirectly by targeting the Arp2/3 complex, a key regulator of actin polymerization. By inhibiting Arp2/3, CK-666 disrupts the formation of branched actin networks, influencing actin dynamics. The indirect modulation of Calponin 3 by CK-666 involves interference with the Arp2/3-mediated events that impact actin cytoskeleton regulation, influencing cellular processes regulated by Calponin 3. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Swinholide A inhibits Calponin 3 indirectly by disrupting actin polymerization. Similar to Cytochalasin D, Swinholide A binds to actin filaments, preventing further polymerization and affecting actin dynamics. The indirect modulation of Calponin 3 by Swinholide A involves alterations in the actin cytoskeleton, impacting cellular processes regulated by Calponin 3 through its interactions with actin filaments. | ||||||