C9orf38 Activators
Forskolin and 2-APB, works by modulating secondary messenger systems such as cAMP and calcium, respectively. These messengers are ubiquitous in cellular signaling, and their regulation is critical for the activation of a broad range of kinases and other proteins. U0126 and PD98059 both target the MAPK/ERK pathway, a key regulator of cell proliferation and differentiation, and their inhibition can result in altered phosphorylation patterns of proteins. Ionomycin and Thapsigargin elevate intracellular calcium levels, triggering a cascade of calcium-dependent signaling events that can affect protein activity. LY333531 and Rapamycin focus on kinase inhibition, specifically targeting protein kinase C and mTOR, respectively, to modulate signaling pathways involved in cell growth and metabolism.
SP600125 and SB431542 intervene in the JNK and TGF-beta pathways, which are involved in stress responses and cell growth regulation. By inhibiting these pathways, these compounds can indirectly influence the activity of various proteins. AICAR, by activating AMPK, can alter metabolic signaling, with broad implications for protein activity due to the central role of metabolism in cell function. Curcumin demonstrates a wide range of effects on cellular pathways, including the inhibition of NF-kB, a transcription factor involved in immune response and cell survival. By modulating such pathways, Curcumin can affect the activity of numerous proteins within these signaling networks.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
Modulates IP3 receptors and calcium release, which can activate calcium-dependent protein kinases affecting protein activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
Inhibits MEK1/2, altering ERK pathway signaling, which can impact protein phosphorylation and activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium concentration, which can activate calmodulin and calmodulin-dependent protein kinases, affecting protein activity. | ||||||
LY-333,531 Hydrochloride | 169939-93-9 | sc-364215 sc-364215A | 1 mg 5 mg | $92.00 $281.00 | 6 | |
Inhibits protein kinase C beta, which can impact PKC-mediated signaling pathways and potentially protein function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Inhibits mTOR, which can affect protein synthesis and downstream signaling pathways, possibly influencing protein activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
Inhibits JNK, which can modulate the JNK signaling pathway, affecting the activity of target proteins. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
Inhibits TGF-beta receptor, which can alter SMAD signaling and thus potentially affect protein function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Inhibits MEK, which can alter ERK pathway signaling, potentially impacting protein phosphorylation and activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Induces ER stress by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase, which can affect calcium signaling and protein activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
Activates AMPK, which can influence metabolic pathways and potentially modulate protein activity. | ||||||