C6orf132 Activators
Chemical activators of C6orf132 can engage with the protein in various ways to modulate its activity, primarily through the alteration of phosphorylation states. Forskolin, by directly activating adenylate cyclase, increases the levels of intracellular cAMP. This surge in cAMP can lead to the activation of protein kinase A (PKA), which is known to phosphorylate a multitude of substrates, including C6orf132. Similarly, 8-Bromo-cAMP, a cell-permeable analog of cAMP, also activates PKA, which in turn can phosphorylate C6orf132. On a different pathway, Ionomycin increases intracellular calcium concentration, which can activate calmodulin-dependent kinases, capable of phosphorylating C6orf132 within calcium signaling pathways. Thapsigargin, by inhibiting SERCA, also raises cytosolic calcium levels, potentially inducing the activation of kinases that phosphorylate C6orf132.
Furthermore, Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which then can phosphorylate C6orf132 as part of the PKC signaling cascade. Inhibitors of protein phosphatases such as Okadaic Acid and Calyculin A lead to an increased phosphorylation state of proteins by preventing their dephosphorylation, which could result in the activation of C6orf132. Anisomycin, by activating stress-activated protein kinases such as JNK, and Spermine, through its influence on calcium channels, can both lead to the phosphorylation and consequent activation of C6orf132. Zaprinast and Spermine NONOate, which elevate cGMP levels, activate PKG that can phosphorylate C6orf132. Lastly, Bisindolylmaleimide I, although typically a PKC inhibitor, under certain conditions, can paradoxically activate PKC, potentially leading to the phosphorylation of C6orf132. Each of these chemicals, through their distinct mechanisms, can contribute to the modulation of C6orf132 activity within cellular signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as a calcium ionophore, increasing intracellular calcium concentration. This rise in calcium can activate calmodulin-dependent kinases, which are capable of phosphorylating and activating C6orf132 within calcium signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate a broad range of substrates, including proteins like C6orf132, as part of the PKC signaling cascade. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of proteins. This can result in the activation of C6orf132 through the prevention of its dephosphorylation within various signaling pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates stress-activated protein kinases like JNK, which can lead to the phosphorylation and activation of proteins involved in the MAPK signaling pathway, including C6orf132. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is another inhibitor of protein phosphatases PP1 and PP2A, which leads to the accumulation of phosphorylated proteins and could activate C6orf132 by preventing its dephosphorylation within its respective signaling pathways. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast inhibits phosphodiesterase 5, which increases cGMP levels in cells. Elevated cGMP can activate PKG, and PKG can phosphorylate and activate proteins like C6orf132 within the cGMP signaling pathways. | ||||||
Spermine NONOate | 136587-13-8 | sc-202816 sc-202816A | 5 mg 25 mg | $52.00 $192.00 | 5 | |
Spermine NONOate releases nitric oxide which can elevate cGMP levels, similar to Zaprinast, leading to the activation of PKG and subsequent phosphorylation and activation of C6orf132. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
Bisindolylmaleimide I, though generally a PKC inhibitor, can under certain conditions paradoxically activate PKC, leading to the phosphorylation and activation of proteins, potentially including C6orf132, within the PKC signaling pathway. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. PKA then can phosphorylate and activate proteins, including C6orf132, within the cAMP-dependent signaling pathways. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $60.00 $192.00 $272.00 $883.00 | 1 | |
Spermine can influence calcium channels and indirectly modulate kinase activity. This can lead to the activation of proteins such as C6orf132 through calcium-dependent signaling pathways. | ||||||