C6orf103 Activators
Chemical activators of C6orf103 can induce its activation through various mechanisms involving different signaling pathways and kinases. Phorbol 12-myristate 13-acetate (PMA) directly stimulates Protein Kinase C (PKC), which is a family of kinases known to modify a wide array of proteins through phosphorylation. If C6orf103 is among the substrates of PKC, its activation could be directly influenced by PMA. Similarly, Forskolin, by elevating intracellular cAMP, leads to the activation of Protein Kinase A (PKA), another kinase that phosphorylates numerous proteins. C6orf103, if it is a substrate of PKA, would become activated as a result of Forskolin's action. In parallel, Ionomycin, by increasing intracellular calcium levels, can trigger the activation of calcium/calmodulin-dependent protein kinases, which might then phosphorylate C6orf103, assuming it is a target for these kinases. Thapsigargin contributes to this calcium-mediated pathway by inhibiting SERCA, causing an increase in cytosolic calcium that similarly could activate C6orf103 through calcium-dependent protein kinases.
Continuing with this theme, Calyculin A and Okadaic Acid prevent the dephosphorylation of proteins by inhibiting phosphatases like PP1 and PP2A. This inhibition can lead to a sustained phosphorylated state of proteins, among them possibly C6orf103, thereby maintaining its active state. Anisomycin activates stress-activated protein kinases such as JNK, which can phosphorylate C6orf103 if it is a suitable substrate. Zinc Pyrithione is known to stimulate the MAPK pathway, which can lead to the activation of various proteins, potentially including C6orf103, through phosphorylation. Hydrogen Peroxide, as a reactive oxygen species, can activate secondary messenger pathways that involve kinases capable of modifying C6orf103. Lastly, compounds like S-Nitroso-N-acetylpenicillamine, by releasing nitric oxide, activate guanylyl cyclase and subsequently PKG, and Staurosporine and Bisindolylmaleimide I, through their nuanced effects on kinases, can lead to the activation of C6orf103 through kinase-mediated phosphorylation.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
This compound directly activates Protein Kinase C (PKC). PKC, in turn, is known to phosphorylate a myriad of proteins. Given that C6orf103 is a protein, activation of PKC by Phorbol 12-myristate 13-acetate can lead to the phosphorylation and activation of C6orf103, assuming C6orf103 is a substrate of PKC. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that elevates intracellular calcium levels. Increased calcium can activate calcium/calmodulin-dependent protein kinases, which may phosphorylate and activate C6orf103 if it is a substrate of these kinases. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels. This elevation in calcium can activate calcium-dependent kinases that are capable of phosphorylating and activating C6orf103. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). Inhibition of these phosphatases leads to increased phosphorylation levels of proteins, potentially resulting in the activation of C6orf103 through sustained phosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Similar to Calyculin A, Okadaic Acid inhibits protein phosphatases, particularly PP1 and PP2A, potentially maintaining C6orf103 in a phosphorylated and active state. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates stress-activated protein kinases like JNK. If C6orf103 is a substrate to these kinases, its phosphorylation and subsequent activation would occur upon exposure to Anisomycin. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Pyrithione has been shown to activate the mitogen-activated protein kinase (MAPK) pathway. The MAPKs that are activated can phosphorylate and activate C6orf103 if it is among their substrates. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen Peroxide is a reactive oxygen species that can act as a secondary messenger in various signal transduction pathways, including the activation of kinases that could phosphorylate and activate C6orf103. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $73.00 $112.00 $367.00 | 18 | |
This compound releases nitric oxide which can activate guanylyl cyclase, leading to increased cGMP levels and activation of Protein Kinase G (PKG). PKG can phosphorylate and activate C6orf103 if it is a target for PKG-mediated phosphorylation. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Although known primarily as a kinase inhibitor, Staurosporine at low concentrations can paradoxically activate some kinases. Activation of these kinases could result in phosphorylation and activation of C6orf103. | ||||||