C6 Activators
C6 Activators are instrumental chemical compounds that indirectly augment the functional activity of C6 through specific pathways. Phorbol 12-myristate 13-acetate (PMA) is a powerful activator of protein kinase C (PKC), which is directly involved in the complement system's activation, including the assembly and lytic function of C6 within the membrane attack complex (MAC). Similarly, arachidonic acid can initiate the synthesis of eicosanoids that potentiate the complement system's activation, thereby indirectly enhancing the activity of C6 in immune responses. ATP acts as a signaling molecule that can provoke a rise in inflammation and subsequent complement activation, which may indirectly increase C6 activity, while zymosan triggers the alternative pathway of complement activation, directly leading to an upsurge in C6 activity essential for cell lysis.
Furthermore, Cobalt (II) chloride acts as a hypoxia-mimetic agent, potentially leading to the upregulation of complement components and enhancement of C6 activity in inflammatory settings. DCCD disrupts cellular energy metabolism, which can incite a cell stress response that includes complement activation and thus C6 activity augmentation. Concanavalin A engages the lectin pathway of complement activation, which complements the function of C6 by promoting the formation of the MAC. Eicosapentaenoic acid (EPA) gives rise to mediators that, despite their typical association with anti-inflammatory processes, can also enhance C6 activity in the formation of the MAC. Lastly, Glycyrrhizin from licorice root modulates immune functions, including the complement system, potentially leading to an increase in the functional activity of C6 in immune complex clearance and cell lysis. Collectively, these chemicals target distinct pathways that converge on the activation of C6, facilitating its role in the defense mechanisms of the immune system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which has been implicated in the activation of the complement system. PKC activation can lead to the phosphorylation of complement component C6, thereby enhancing its assembly into the membrane attack complex (MAC) and lytic activity. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
As a precursor to eicosanoids, arachidonic acid can initiate the formation of lipid mediators that modulate inflammation and immunity. These eicosanoids can enhance the activation of the complement system, thus indirectly increasing the functional activity of C6 in immune responses. | ||||||
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
ATP, released by cells under stress or during apoptosis, can act as a signaling molecule. It has been shown to activate the purinergic receptor P2X, which could lead to an increase in the inflammatory response and subsequent complement activation, thereby indirectly enhancing the activity of C6. | ||||||
Zymosan | 9010-72-4 | sc-296863 sc-296863A | 100 mg 1 g | $99.00 $599.00 | 1 | |
Zymosan is a glucan from yeast cell walls that can activate complement via the alternative pathway. This activation leads to an increase in C6 activity as part of the complement cascade, ultimately contributing to the formation of the MAC and the lysis of targeted cells. | ||||||
DCC | 538-75-0 | sc-239713 sc-239713A | 25 g 100 g | $72.00 $208.00 | 3 | |
DCC ,or DCCD, is known to inhibit mitochondrial ATPase, causing a disturbance in cellular energy metabolism. This disruption can lead to a cell stress response that may include the activation of the complement system, thereby indirectly enhancing the activity of C6. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $119.00 $364.00 $947.00 | 17 | |
Concanavalin A is a lectin known to bind carbohydrates and can activate the lectin pathway of complement activation. This pathway is synergistic with C6 function, enhancing the formation of the MAC and the effector functions of the complement system. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
EPA, a polyunsaturated fatty acid, can give rise to anti-inflammatory eicosanoids that modulate the complement system. While typically associated with anti-inflammatory processes, EPA-derived mediators can also enhance the activity of C6 in the formation of the MAC. | ||||||
Glycyrrhizic acid | 1405-86-3 | sc-279186 sc-279186A | 1 g 25 g | $57.00 $333.00 | 7 | |
Glycyrrhizin is a compound found in licorice root with various effects on immune function. It can modulate the complement system's activity, potentially leading to an increased functional activity of C6 in immune complex clearance and cell lysis. | ||||||