C5orf29 Activators
AMPK Activators encompass a range of chemical compounds that enhance the catalytic activity of AMPK, a critical energy-sensing enzyme that plays a pivotal role in cellular energy homeostasis. Direct activators such as A-769662 and SBI-0206965 interact with specific subunits of AMPK, leading to allosteric changes that protect the enzyme from dephosphorylation and augment its activity. AICAR and Berberine function by mimicking the natural activator AMP, binding to AMPK and activating it by promoting the phosphorylation of its activation loop. Similarly, PT1 and GSK621 act by binding to distinct sites on AMPK, inducing conformational changes that prevent dephosphorylation or enhance phosphorylation, respectively, thereby activating the enzyme.
On the other hand, indirect activators like Metformin and Phenformin elevate the AMP/ATP ratio by inhibiting mitochondrial complex I, which signals to AMPK to conserve energy, leading to its activation. These compounds, along with Salicylate, which binds directly to AMPK, and Resveratrol, which activates via the SIRT1-LKB1 pathway, diversify the range of mechanisms by which AMPK can be activated. The biochemical implications of activating AMPK are numerous, as it is a central regulator of metabolic pathways. Compounds such as Quercetin activate AMPK by affecting upstream kinases or altering energy levels within the cell, which can lead to enhanced phosphorylation and activation of the kinase.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. This elevation can activate calcium-dependent protein kinases, which could phosphorylate and enhance the activity of C5orf29, assuming C5orf29 is regulated by calcium-mediated signaling pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC) which is involved in various signaling pathways. Activation of PKC may lead to phosphorylation of C5orf29 or proteins that modulate C5orf29 activity, resulting in its functional enhancement. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol compound from green tea with kinase inhibition properties. By inhibiting certain kinases, EGCG may reduce negative regulatory influences on C5orf29, indirectly enhancing its activity. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Br-cAMP is a cell-permeable cAMP analog that activates PKA. Activation of PKA can lead to phosphorylation events that enhance the activity of C5orf29 through direct or indirect interactions. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a synthetic beta-adrenergic agonist that increases cAMP levels via stimulation of beta-adrenergic receptors. The subsequent activation of PKA may enhance C5orf29 activity through phosphorylation. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a sesquiterpene lactone that inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), leading to increased cytosolic calcium levels. This influx of calcium may activate calcium-dependent kinases that enhance the activity of C5orf29. | ||||||
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $116.00 $179.00 $265.00 $369.00 $629.00 $1150.00 | ||
db-cAMP is a cAMP analog that is resistant to degradation by phosphodiesterases. It activates PKA, potentially leading to the phosphorylation and enhancement of C5orf29 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, LY294002 may shift the balance of downstream signaling pathways, potentially enhancing signaling pathways that activate C5orf29. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels, which could activate calcium-sensitive kinases and phosphatases that modulate C5orf29 function. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO is often used as a solvent for biological studies, but it also has the capacity to alter membrane permeability and influence signaling pathways. While not a direct activator of C5orf29, it may modulate cellular environments in a way that enhances the activity of C5orf29. | ||||||