C2orf68_0610030E20Rik Inhibitors

Inhibitors like staurosporine and U0126 function by hindering the activity of kinases, which are crucial for the phosphorylation and activation of many proteins involved in signaling pathways. Compounds such as LY294002 and wortmannin target specific kinases within the PI3K/AKT/mTOR pathway, a central conduit for signals that regulate cell growth, proliferation, and survival. These inhibitors can modulate the activity of proteins that are regulated by phosphorylation and dephosphorylation events.

Likewise, rapamycin and its analogs inhibit the mTOR pathway, which is deeply integrated with protein synthesis and autophagy, affecting a wide array of cellular functions. Brefeldin A and cycloheximide, on the other hand, disrupt fundamental cellular processes such as protein transport and synthesis, respectively, thus impacting protein function on a broad scale. Compounds such as 2-Deoxy-D-glucose interfere with energy production pathways like glycolysis, which could impact proteins that require ATP for their activity. MG132 inhibits the ubiquitin-proteasome system, leading to the accumulation of proteins that are usually targeted for degradation, potentially affecting protein turnover and function.