C2CD2 Activators
C2CD2, or calcium-dependent domain-containing protein 2, is a biological molecule that has garnered interest in the field of molecular biology due to its intricate role in cellular processes. The gene encoding C2CD2 is expressed in various tissues, implicating its significance in diverse cellular functions. The expression of C2CD2, like many genes, is subject to precise regulatory mechanisms, ensuring that protein levels are synchronized with the cell's physiological needs. Understanding the factors that can induce the expression of C2CD2 is critical for elucidating its function and role within the cellular framework. Research has identified that certain chemicals can serve as activators, triggering a cascade of intracellular events that lead to the upregulation of C2CD2 expression. These activators interact with cellular components, influencing signaling pathways, transcription factor activity, and epigenetic modifications, which collectively contribute to the transcriptional activation of the C2CD2 gene.
Among the array of compounds capable of inducing C2CD2 expression, several have been noted for their effect on gene expression through epigenetic alterations. Compounds like 5-Azacytidine and Trichostatin A are known to modify the epigenetic landscape, thereby removing barriers to transcription and facilitating the expression of genes, potentially including C2CD2. Similarly, signaling molecules such as Forskolin can elevate intracellular second messengers like cAMP, which in turn activate protein kinase pathways leading to the transcription of target genes. Moreover, natural compounds such as retinoic acid and β-Estradiol bind to their respective receptors, initiating transcriptional programs that can result in the enhanced expression of a suite of genes. Interestingly, even lifestyle-associated substances like the polyphenol Epigallocatechin gallate (EGCG), found in green tea, have been posited to exert an influence on gene expression, suggesting a link between dietary components and gene regulation. Collectively, these activators work through diverse mechanisms to upregulate C2CD2, demonstrating the intricate web of control that orchestrates gene expression within the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may upregulate C2CD2 expression by engaging retinoic acid receptors that bind to retinoic acid response elements in the DNA, initiating transcriptional activation of target genes, including potentially C2CD2. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferases, 5-Azacytidine could lead to the hypomethylation of gene promoter regions and thereby stimulate the upsurge in C2CD2 transcription, as part of its genome-wide demethylating effect. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may stimulate the transcription of C2CD2 by preventing the deacetylation of histones, facilitating a relaxed chromatin conformation that is conducive to increased transcriptional activity of several genes, including C2CD2. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates intracellular cAMP levels, thereby activating protein kinase A (PKA) which can lead to the activation of transcription factors and an upsurge in the transcription of cAMP-responsive genes, potentially including C2CD2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA may increase C2CD2 expression by activating PKC, which subsequently activates transcription factors like NF-κB; these factors can bind to promoter regions of genes like C2CD2, resulting in enhanced transcriptional activity. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, by inhibiting histone deacetylases, could stimulate a permissive chromatin state that enhances the transcriptional activation of several genes, including potentially C2CD2, as part of broader epigenetic shifts in gene expression. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
By inhibiting GSK-3, lithium chloride may stimulate the Wnt signaling cascade, which has been implicated in the transcriptional upregulation of a subset of genes, among which C2CD2 could be a target, given its broad expression pattern. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate, through its antioxidant properties, may create a cellular environment that stimulates the transcriptional activity of various genes, potentially leading to the upregulation of C2CD2 expression through redox-sensitive transcription factors and signaling pathways. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone may induce C2CD2 expression by activating glucocorticoid receptors that bind to glucocorticoid response elements in the promoters of responsive genes, which might include C2CD2, leading to increased transcriptional activity. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
As a potent estrogen, β-Estradiol may stimulate the expression of C2CD2 by binding to estrogen receptors, which then interact with estrogen response elements on the DNA to initiate gene transcription, potentially elevating levels of C2CD2. | ||||||