C20orf160 Activators

CCM2-like scaffold protein, also known as CCM2L or Cerebral Cavernous Malformations 2-like protein, is a protein that shares homology with the CCM2 protein, which is a critical component of the CCM signaling complex involved in cardiovascular development and integrity. The CCM complex, comprising CCM1 (KRIT1), CCM2 (Malcavernin), and CCM3 (PDCD10), plays a pivotal role in maintaining vascular stability by regulating endothelial junctions and controlling endothelial permeability.CCM2L is thought to function similarly to CCM2 by acting as a scaffold protein. Scaffold proteins are crucial for assembling various signaling proteins into complexes, thereby facilitating specific downstream signaling pathways. In the context of the CCM signaling pathway, these complexes are essential for the proper formation and maintenance of blood vessels, and mutations in any of the CCM proteins can lead to cerebral cavernous malformations (CCMs)-vascular lesions in the brain that are subject to hemorrhage.

Although the specific biological functions of CCM2L are not as well-elucidated as those of CCM2, the structural similarity suggests that CCM2L may be involved in the same or parallel pathways that regulate endothelial cell function. It may compensate for CCM2 function or provide redundancy in the signaling pathways that control vascular development and stability. Research into CCM2L's role in endothelial signaling could provide deeper insights into the molecular mechanisms underlying vascular diseases. Since CCMs can result in significant neurological problems, understanding the contribution of proteins like CCM2L to vascular biology could be critical in developing novel interventions for these and related vascular conditions.