C12orf59_D630042F21Rik Activators
Chemical activators of C12orf59_D630042F21Rik can facilitate its functional activation through various cell signaling pathways. Forskolin, by directly activating adenylate cyclase, increases intracellular cAMP levels, which in turn activates protein kinase A (PKA). PKA then selectively phosphorylates specific substrates, including C12orf59_D630042F21Rik, leading to its activation. Similarly, Ionomycin, acting as a Ca2+ ionophore, elevates intracellular calcium concentrations, which can activate Ca2+/calmodulin-dependent protein kinases capable of targeting proteins like C12orf59_D630042F21Rik for phosphorylation. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which can phosphorylate and activate a range of proteins; if C12orf59_D630042F21Rik is among its substrates, this would lead to its activation. Additionally, Epidermal Growth Factor (EGF) stimulates its receptor, triggering the MAPK/ERK pathway, which can phosphorylate multiple proteins, potentially including C12orf59_D630042F21Rik.
Insulin, upon binding to its receptor, initiates a cascade that includes the activation of the PI3K/Akt pathway, where Akt kinase can phosphorylate and activate various cellular substrates. C12orf59_D630042F21Rik, if included in these substrates, would be activated as a result. Spermidine can activate AMP-activated protein kinase (AMPK), which in turn may phosphorylate C12orf59_D630042F21Rik. Hydrogen peroxide acts as an oxidizing agent and can modify kinase and phosphatase activity, possibly leading to the oxidative activation of C12orf59_D630042F21Rik. Resveratrol activates sirtuin proteins, which can deacetylate and activate many substrates; this activity can extend to C12orf59_D630042F21Rik if it is regulated by acetylation. Oleic Acid can activate GPCRs that signal downstream to enzymes that may phosphorylate C12orf59_D630042F21Rik. Zinc Pyrithione facilitates the intracellular increase of zinc ions, which can act as cofactors for enzymes that may phosphorylate C12orf59_D630042F21Rik. Curcumin can inhibit NF-κB signaling, potentially leading to the activation of kinases that phosphorylate C12orf59_D630042F21Rik. Finally, Okadaic Acid, by inhibiting phosphatases 1 and 2A, may result in the sustained phosphorylation and consequent activation of C12orf59_D630042F21Rik.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin acts as an ionophore that selectively binds to Ca2+ and increases its intracellular concentration. Elevated intracellular Ca2+ can activate Ca2+/calmodulin-dependent protein kinases, which might directly phosphorylate and activate C12orf59_D630042F21Rik. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). Activated PKC phosphorylates target proteins, which could include C12orf59_D630042F21Rik if it's a PKC substrate, leading to its activation. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin binds to its receptor, instigating a signaling cascade that includes the activation of the PI3K/Akt pathway. Akt kinase can phosphorylate and activate numerous substrates within the cell, potentially including C12orf59_D630042F21Rik. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine can activate AMP-activated protein kinase (AMPK). Once activated, AMPK can phosphorylate various downstream targets, which might encompass C12orf59_D630042F21Rik, thus promoting its activation. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide acts as an oxidizing agent that can influence the activity of redox-sensitive kinases and phosphatases, potentially leading to the modification and activation of particular proteins, including C12orf59_D630042F21Rik, through oxidative signaling mechanisms. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates the sirtuin family of proteins, which are NAD+-dependent deacetylases. Sirtuins can deacetylate and activate several substrates in the cell. If C12orf59_D630042F21Rik is subject to acetylation, its activation could be mediated by sirtuin activity. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $36.00 $102.00 $569.00 $1173.00 | 10 | |
Oleic Acid can activate G-protein-coupled receptors (GPCRs), triggering downstream signaling pathways that may lead to the activation of enzymes and subsequent phosphorylation of proteins such as C12orf59_D630042F21Rik. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Pyrithione facilitates the transport of zinc ions into the cells. Zinc can act as a cofactor for various enzymes that could directly phosphorylate and activate C12orf59_D630042F21Rik. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB signaling, potentially leading to the activation of alternative signaling pathways. These pathways may include kinases that directly phosphorylate and activate C12orf59_D630042F21Rik. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to sustained phosphorylation of proteins within the cell. This could result in the maintained activation of proteins like C12orf59_D630042F21Rik if it is normally dephosphorylated by these phosphatases. | ||||||