C10orf28 Inhibitors

R3H domain and coiled-coil containing 1-like protein, also known as R3HCC1L, is a protein encoded by the R3HCC1L gene in humans. This protein features two distinct structural motifs: an R3H domain and coiled-coil regions. The R3H domain is a conserved sequence motif found in various proteins and is named after the characteristic spacing of arginine (R) and histidine (H) residues within it. This domain is implicated in binding to single-stranded nucleic acids and is often involved in processes such as RNA metabolism, DNA repair, and gene regulation.The coiled-coil regions of the R3HCC1L protein are structural motifs that facilitate the formation of stable protein-protein interactions. Coiled-coils are characterized by a heptad repeat pattern of hydrophobic amino acids that form a supercoiled structure resembling a rope. These motifs are commonly found in proteins that are involved in forming the cytoskeleton, vesicle transport, and in the function of motor proteins.

The specific biological functions of R3HCC1L remain to be fully elucidated. However, the presence of the R3H domain suggests a role in nucleic acid binding, which could mean involvement in regulatory functions such as transcription, RNA splicing, or stability. Meanwhile, the coiled-coil regions indicate that R3HCC1L might interact with other proteins, possibly participating in the formation of multiprotein complexes or contributing to the structural organization of the cell.Given its domains, R3HCC1L likely plays a role in cellular processes that require the precise regulation of RNA or DNA interactions, combined with the need for structural integrity and dynamics provided by protein-protein interactions. Further research into the R3HCC1L protein will provide a deeper understanding of its function and its potential involvement in human diseases, especially those related to gene expression regulation and cellular structure maintenance.