BHMT2 Activators
BHMT2 is integral to the methylation pathway, transforming homocysteine into methionine, with its activity strongly influenced by the presence of methyl group donors. These donors are not just essential but directly enhance the enzyme's methylation capacity. The enzyme's performance is further nuanced by the availability of its substrates and the feedback from its methylation products. Precursors to these donors indirectly augment BHMT2 activity by boosting substrate levels, while some products can help regulate the overall methylation cycle. In a broader sense, the enzyme's function is also supported by the one-carbon metabolism pathway, in which certain nutrients play a supportive, albeit indirect, role in fortifying the methylation processes that BHMT2 is a part of.
The activity of BHMT2 is additionally modulated by essential cofactors that ensure the enzyme's structural and catalytic properities are optimal. Some elements are pivotal for the enzyme's stability and function. The methylation cycles within which BHMT2 operates reveal a complex network of metabolic interactions; for example, the synthesis of related compounds, which consume methyl donors, may lead to an adaptive increase in their availability, indirectly stimulating BHMT2's activity. Conversely, the presence of certain molecules can exert feedback control on homocysteine methylation pathways, potentially increasing reliance on BHMT2.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
Serves as a primary methyl donor in a variety of biochemical reactions, including the methylation of homocysteine to form methionine, thereby directly increasing BHMT2 activity. | ||||||
Betaine | 107-43-7 | sc-214595 sc-214595A sc-214595B sc-214595C sc-214595D sc-214595E | 50 g 100 g 250 g 1 kg 2.5 kg 5 kg | $31.00 $41.00 $56.00 $163.00 $337.00 $592.00 | 2 | |
Acts as a methyl donor in the BHMT2-catalyzed reaction converting homocysteine to methionine, directly enhancing BHMT2 function. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $33.00 $37.00 $52.00 | 1 | |
Choline can be oxidized to betaine, which in turn participates in the BHMT2-driven pathway to methylate homocysteine, thus indirectly boosting BHMT2 activity. | ||||||
Folic Acid | 59-30-3 | sc-204758 | 10 g | $73.00 | 2 | |
Participates in one-carbon metabolism and indirectly supports BHMT2 by regenerating methionine from homocysteine, which is part of the methylation cycle that includes BHMT2. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $60.00 $90.00 $325.00 $1155.00 $3851.00 $10056.00 | 2 | |
Essential cofactor in the remethylation of homocysteine to methionine, a reaction in which BHMT2 is involved, thus indirectly supporting BHMT2 function. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
As a cofactor, zinc can influence the conformation and catalytic activity of BHMT2, thereby potentially enhancing its enzymatic function. | ||||||
Creatine, anhydrous | 57-00-1 | sc-214774 sc-214774A | 10 mg 50 g | $28.00 $79.00 | 2 | |
Creatine synthesis consumes S-adenosylmethionine, which may lead to a compensatory increase in its production, indirectly involving BHMT2 for homocysteine remethylation. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $37.00 $57.00 $151.00 $577.00 $1103.00 | ||
Methionine can feedback-inhibit the methionine synthase pathway, potentially shifting the homocysteine remethylation burden to BHMT2 and increasing its activity. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $41.00 $112.00 $525.00 | 3 | |
Important for the synthesis of FAD, which is required for the metabolism of homocysteine, indirectly promoting BHMT2 pathway to maintain homocysteine levels. | ||||||
Pyridoxal-5-phosphate | 54-47-7 | sc-205825 | 5 g | $104.00 | ||
The active form of vitamin B6, a cofactor for enzymes in the homocysteine metabolism, indirectly supporting the activity of BHMT2 by facilitating homocysteine clearance. | ||||||