BHMT Inhibitors
BHMT inhibitors, or Betaine-Homocysteine S-Methyltransferase inhibitors, belong to a distinctive class of chemical compounds that play a pivotal role in modulating the intricate biochemical pathways within the human body. These inhibitors primarily target the BHMT enzyme, which is an essential component of the one-carbon metabolism pathway. The BHMT enzyme is responsible for catalyzing the conversion of homocysteine, an amino acid, into methionine, another amino acid crucial for various cellular processes. BHMT inhibitors act by interfering with the enzymatic activity of BHMT, disrupting the conversion of homocysteine to methionine. This alteration can have profound implications for several physiological functions that depend on proper amino acid metabolism.
BHMT serves as a key mechanism for regulating homocysteine levels in the body. Elevated homocysteine levels have been associated with various health issues. BHMT inhibitors, by modulating this enzymatic conversion, can influence homocysteine levels and potentially help in maintaining them within a healthy range. These inhibitors are essential tools in the study of one-carbon metabolism.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Homocysteine | 6027-13-0 | sc-507315 | 250 mg | $195.00 | ||
S-adenosylhomocysteine is a product of transmethylation reactions and can act as a competitive inhibitor of BHMT by binding to the enzyme's active site. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is a cofactor required for BHMT activity. Excess zinc can lead to mismetallation of proteins and inhibit BHMT. | ||||||
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $64.00 $176.00 | 7 | |
Cobalt can displace zinc from its binding sites in metalloproteins, potentially inhibiting BHMT by altering its metal-dependent conformation. | ||||||
Lead(II) Acetate | 301-04-2 | sc-507473 | 5 g | $85.00 | ||
Lead can competitively inhibit zinc-binding sites in metalloenzymes like BHMT, altering their structure and function. | ||||||
Cadmium chloride, anhydrous | 10108-64-2 | sc-252533 sc-252533A sc-252533B | 10 g 50 g 500 g | $56.00 $183.00 $352.00 | 1 | |
Cadmium can replace zinc in metalloproteins, potentially inhibiting BHMT activity. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic compounds can bind to thiol groups in proteins, potentially inhibiting enzymes like BHMT. | ||||||
L-Methionine | 63-68-3 | sc-394076 sc-394076A sc-394076B sc-394076C sc-394076D sc-394076E | 25 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $37.00 $57.00 $151.00 $577.00 $1103.00 | ||
Methionine is the product of the BHMT reaction. Elevated methionine levels can inhibit BHMT activity through product inhibition. | ||||||