beta2-AR Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Carvedilol | 72956-09-3 | sc-200157 sc-200157A sc-200157B sc-200157C sc-200157D | 100 mg 1 g 10 g 25 g 100 g | $124.00 $240.00 $530.00 $999.00 $1530.00 | 2 | |
Carvedilol is characterized by its dual action on beta-adrenergic receptors, particularly beta2-AR, where it exhibits a unique binding affinity due to its chiral centers. The compound's structural conformation allows for effective steric interactions, enhancing receptor selectivity. Its dynamic equilibrium in solution facilitates rapid receptor binding and unbinding, influencing intracellular signaling cascades. Additionally, carvedilol's lipophilicity contributes to its distribution and interaction with membrane-bound proteins. | ||||||
(RS)-Atenolol | 29122-68-7 | sc-204895 sc-204895A | 1 g 10 g | $79.00 $416.00 | 1 | |
(RS)-Atenolol demonstrates a selective affinity for beta2-adrenergic receptors, influenced by its stereochemistry. The compound's unique spatial arrangement promotes specific hydrogen bonding and hydrophobic interactions, optimizing receptor engagement. Its kinetic profile reveals a rapid association and dissociation rate, allowing for transient modulation of signaling pathways. Furthermore, (RS)-Atenolol's solubility characteristics enhance its interaction with lipid membranes, impacting its overall bioavailability and receptor accessibility. | ||||||
Bucindolol | 71119-11-4 | sc-203860 sc-203860A | 10 mg 50 mg | $250.00 $785.00 | 2 | |
Bucindolol exhibits a distinctive interaction with beta2-adrenergic receptors, characterized by its ability to stabilize receptor conformations through unique electrostatic and van der Waals forces. This compound's dynamic binding kinetics facilitate a nuanced modulation of downstream signaling cascades. Additionally, Bucindolol's lipophilic nature enhances its membrane permeability, allowing for effective receptor localization and interaction, which may influence its overall pharmacodynamics. | ||||||
ICI 118,551 hydrochloride | 72795-01-8 | sc-361206 | 10 mg | $254.00 | 2 | |
ICI 118,551 hydrochloride is a selective beta2-adrenergic receptor antagonist that demonstrates unique binding affinity, characterized by its ability to induce specific conformational changes in the receptor. This compound exhibits rapid association and dissociation kinetics, allowing for precise modulation of receptor activity. Its hydrophilic properties enhance solubility, facilitating interactions with membrane-bound proteins and influencing intracellular signaling pathways. | ||||||
CGP 12177 hydrochloride | 81047-99-6 | sc-203878 sc-203878A | 10 mg 50 mg | $87.00 $281.00 | ||
CGP 12177 hydrochloride is a potent beta2-adrenergic receptor agonist known for its unique ability to stabilize receptor conformations, promoting distinct signaling cascades. Its high affinity for the receptor leads to enhanced activation of downstream effectors, influencing cyclic AMP production. The compound's lipophilic characteristics contribute to its membrane permeability, allowing for effective engagement with lipid bilayers and modulating receptor dynamics in various cellular environments. | ||||||
SR 59230A hydrochloride | 1135278-41-9 | sc-204302 sc-204302A | 10 mg 50 mg | $383.00 $1533.00 | 3 | |
SR 59230A hydrochloride acts as a selective antagonist at beta2-adrenergic receptors, exhibiting unique binding kinetics that favor a prolonged interaction with the receptor. This compound disrupts typical receptor signaling pathways, leading to altered intracellular calcium levels and inhibition of cyclic AMP accumulation. Its distinct molecular structure enhances its affinity for the receptor, allowing for specific modulation of receptor activity and influencing downstream physiological responses. | ||||||
4-Amino-1-benzylpiperidine | 50541-93-0 | sc-254592 sc-254592A | 5 g 25 g | $32.00 $94.00 | ||
4-Amino-1-benzylpiperidine functions as a beta2-adrenergic receptor modulator, characterized by its ability to engage in specific hydrogen bonding and hydrophobic interactions with the receptor's binding site. This compound exhibits unique conformational flexibility, enabling it to stabilize receptor states that influence G-protein coupling efficiency. Its kinetic profile suggests a rapid onset of action, with potential for nuanced regulation of receptor-mediated signaling cascades, impacting various cellular processes. | ||||||
rac Propranolol β-D-Glucuronide Sodium Salt | 66322-66-5 non-salt | sc-219873 | 1 mg | $380.00 | ||
Rac Propranolol β-D-Glucuronide Sodium Salt acts as a beta2-adrenergic receptor modulator, distinguished by its capacity for selective ionic interactions and steric complementarity within the receptor's active site. This compound demonstrates a unique affinity for allosteric sites, potentially altering receptor conformation and enhancing signal transduction pathways. Its dynamic solubility and stability in aqueous environments facilitate effective molecular interactions, influencing downstream cellular responses. | ||||||