β-tectorin Activators
β-tectorin Activators are a select group of chemical compounds that indirectly enhance the functional activity of β-tectorin by interfacing with various signaling pathways, thereby influencing the protein's role in the biomechanics of hearing. Forskolin, for instance, by elevating cAMP levels, indirectly promotes β-tectorin's function by activating PKA, which subsequently may phosphorylate β-tectorin, enhancing its structural role within the tectorial membrane. Ionomycin and A23187, both calcium ionophores, increase intracellular calcium levels and could thus bolster calcium-dependent signaling pathways, potentially augmenting the interaction of β-tectorin with other proteins critical for hearing. PMA, as a PKC activator, and Rolipram, a PDE4 inhibitor, similarly may lead to modifications such as phosphorylation of β-tectorin, thereby potentially improving its structural integrity and function in sound transduction.
Moreover, the inhibition of protein phosphatases by Okadaic acid may result in a sustained phosphorylation state of β-tectorin, conceivably enhancing its role in the cochlea. Anisomycin, while inhibiting protein synthesis, activates JNK signaling that could lead to increased phosphorylation of cochlear proteins, including β-tectorin, potentially reinforcing its functional role. SNAP, through the release of nitric oxide, and Zaprinast, by inhibiting PDE5, both increase the levels of cGMP, which may activate PKG and contribute to the phosphorylation and enhancement of β-tectorin's activity. BAY 60-7550 and LY294002, by modulating levels of cAMP and PI3K/AKT signaling respectively, could also influence the phosphorylation dynamics, indirectly leading to an upsurge in β-tectorin's activity, which is instrumental in the mechanical processes of hearing. Together, these β-tectorin Activators, through their targeted impact on cellular signaling cascades, facilitate the enhancement of β-tectorin's role in the auditory mechanism without direct activation or upregulation of its expression.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which could phosphorylate proteins including β-tectorin, potentially enhancing its role in the structural integrity of tectorial membrane. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore elevating intracellular Ca²⁺ levels, which can activate Ca²⁺-dependent signaling pathways. For β-tectorin, this may enhance its interaction with other structural proteins in the cochlea, influencing hearing mechanics. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in various signaling cascades. PKC activation can lead to post-translational modifications of β-tectorin, potentially enhancing its function within the tectorial membrane. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram inhibits phosphodiesterase-4, preventing cAMP breakdown, thus indirectly increasing PKA activity. This could promote the phosphorylation and activation of cochlear proteins, including β-tectorin, affecting its role in sound transduction. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, preventing dephosphorylation of proteins. This could result in the sustained phosphorylation state of β-tectorin, potentially enhancing its structural role in the ear. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates JNK signaling. Through JNK pathway activation, there may be an increase in phosphorylation events within the cochlea, potentially augmenting β-tectorin's functional role. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $73.00 $112.00 $367.00 | 18 | |
SNAP releases nitric oxide, which can activate guanylyl cyclase, increasing cGMP levels. Raised cGMP can enhance PKG activity, which may phosphorylate cochlear proteins, including β-tectorin, and contribute to the mechanics of hearing. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cAMP analog that activates PKA. PKA activation can lead to phosphorylation of cochlear proteins, enhancing the functional activity of β-tectorin in the tectorial membrane. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast inhibits phosphodiesterases, particularly PDE5, leading to increased cGMP levels and PKG activation. PKG-mediated phosphorylation events in the cochlea may enhance β-tectorin's activity and its role in auditory function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore, which increases intracellular calcium levels, potentially triggering calcium-sensitive signaling pathways that could enhance the structural stability and function of β-tectorin in the tectorial membrane. | ||||||