BCS1L Activators
BCS1L activators represent a diverse group of chemical compounds that enhance the functional activity of BCS1L through specific biochemical pathways or cellular processes. For instance, 2-Deoxy-D-Glucose, a glucose analog inhibits glycolysis, causing a shift towards oxidative phosphorylation, in which BCS1L plays a crucial role as a chaperone for Rieske iron-sulfur protein, a component of the respiratory chain complex III. On the other hand, compounds such as Coenzyme Q10, a component of the electron transport chain, can enhance the functional activity of BCS1L by increasing electron flux through complex III.
Compounds like Sodium Pyruvate and Sodium Succinate, intermediates of the citric acid cycle, boost the citric acid cycle, leading to increased NADH and FADH2 for the electron transport chain, which includes BCS1L-associated complex III, thereby enhancing BCS1L functional activity. Inhibitors of succinate dehydrogenase such as Malonate and Sodium Malonate increase the demand for complex I and by extension, complex III, thus enhancing functional activity of BCS1L. Dichloroacetate, a pyruvate dehydrogenase kinase inhibitor, similarly drives the shift toward oxidative phosphorylation, leading to increased demand for BCS1L-associated complex III activity. Lastly, Teneligliptin, a DPP-4 inhibitor, increases GLP-1, promoting insulin secretion and thus increasing glucose uptake and metabolism, leading to increased oxidative phosphorylation and demand for BCS1L-associated complex III activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-Glucose is a glucose analog that inhibits glycolysis. Inhibition of glycolysis can cause a shift towards oxidative phosphorylation, in which BCS1L plays a crucial role as a chaperone for Rieske iron-sulfur protein, a component of the respiratory chain complex III. The increased demand for oxidative phosphorylation can enhance BCS1L functional activity. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 is a component of the electron transport chain, acting as an electron carrier between complexes I/II and III. Increased Coenzyme Q10 can lead to increased electron flux through complex III, thus potentially enhancing the functional activity of BCS1L. | ||||||
Sodium dichloroacetate | 2156-56-1 | sc-203275 sc-203275A | 10 g 50 g | $54.00 $205.00 | 6 | |
Dichloroacetate is a pyruvate dehydrogenase kinase inhibitor. It drives the shift toward oxidative phosphorylation, leading to increased demand for BCS1L-associated complex III activity. This increased demand can enhance BCS1L functional activity. | ||||||
DCC | 538-75-0 | sc-239713 sc-239713A | 25 g 100 g | $71.00 $204.00 | 3 | |
N,N'-Dicyclohexylcarbodiimide is an uncoupler of oxidative phosphorylation in mitochondria. Its action on mitochondria leads to increased reliance on complex III, where BCS1L functions as a chaperone. This increased reliance on complex III can enhance the functional activity of BCS1L. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium Azide is an inhibitor of cytochrome c oxidase in the electron transport chain. By inhibiting cytochrome c oxidase, Sodium Azide increases reliance on complex III, where BCS1L functions as a chaperone, thus enhancing BCS1L functional activity. | ||||||
Teneligliptin | 760937-92-6 (free base) | sc-475074 | 25 mg | $260.00 | 1 | |
Teneligliptin is a DPP-4 inhibitor that increases GLP-1, an incretin hormone that promotes insulin secretion. The resultant increase in insulin can enhance glucose uptake and metabolism, leading to increased oxidative phosphorylation and demand for BCS1L-associated complex III activity. | ||||||