BAT5 Activators
BAT5 Activators are a class of chemical compounds that directly or indirectly enhance the functional activity of BAT5 by interacting with specific signaling pathways or biological processes. PMA and Ionomycin enhance BAT5 activity through the activation of PKC and calcium-dependent kinases, respectively. Both these compounds lead to the phosphorylation of proteins directly interacting with BAT5. Forskolin, through the elevation of cAMP, activates PKA which in turn can phosphorylate proteins within BAT5's signaling network. U-73122 and the phosphatase inhibitors Okadaic acid and Calyculin A modulate the phosphorylation status of proteins in BAT5's pathway, thereby affecting its activity.
Anisomycin activates stress-activated protein kinases, which can include pathways where BAT5 is involved, enhancing its activity. Thapsigargin and Cyclopiazonic acid disrupt calcium homeostasis, influencing BAT5 activity by activating calcium-dependent signaling. Prostaglandin E2, through its G-protein-coupled receptors, increases cyclic AMP levels, which in turn can enhance BAT5 activity by stimulating PKA to phosphorylate proteins within the signaling network of BAT5. Phosphatidic acid serves as a secondary messenger to modulate protein interactions with BAT5, while Sphingosine-1-phosphate activates G-protein-coupled receptors that can lead to the activation of kinases, which phosphorylate proteins that are part of the functional network of BAT5, thus enhancing its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which in turn phosphorylates various proteins involved in cellular signaling and trafficking. BAT5 functional activity is enhanced through PKC-mediated signaling pathways that directly phosphorylate proteins that interact with BAT5, resulting in increased BAT5 activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Elevated calcium levels can activate calcium-sensitive signaling pathways that BAT5 is part of, leading to enhanced BAT5 activity through stimulation of calcium-dependent protein kinases that directly phosphorylate BAT5 or its associated proteins. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, which in turn increases intracellular cAMP levels. Elevated cAMP enhances protein kinase A (PKA) activity, which can phosphorylate proteins within pathways where BAT5 is involved, leading to increased BAT5 functional activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels of cellular proteins. This inhibition can lead to enhanced BAT5 activity by preventing the dephosphorylation of proteins that are part of BAT5's signaling network. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Similar to okadaic acid, Calyculin A inhibits protein phosphatases, resulting in increased phosphorylation of proteins involved in BAT5's signaling pathways, enhancing BAT5's functional activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs), leading to enhanced BAT5 activity through stress response signaling pathways that include BAT5. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to an increase in cytosolic calcium levels, indirectly enhancing BAT5 activity by activating calcium-dependent proteins and pathways that modulate BAT5's function. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $173.00 $612.00 | 3 | |
Cyclopiazonic acid is another inhibitor of the SERCA pump, increasing intracellular calcium levels and potentially enhancing BAT5 activity through similar mechanisms as thapsigargin, by stimulating calcium-dependent signaling pathways involving BAT5. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 activates its G-protein-coupled receptors, leading to increased intracellular cyclic AMP levels. This activation can enhance BAT5 activity by stimulating PKA, which then phosphorylates proteins within BAT5's signaling network. | ||||||
Phosphatidic Acid, Dioleoyl | 108392-02-5 | sc-201059 | 10 mg | $250.00 | 1 | |
Phosphatidic acid can act as a secondary messenger within cell signaling pathways, potentially enhancing BAT5 activity by modulating the localization and function of proteins that interact with BAT5 within those pathways. | ||||||