BART1 Inhibitors
Chemical inhibitors of BART1 function primarily through their interactions with the microtubule network within cells. Microtubules are critical components of the cellular cytoskeleton, and their dynamic polymerization and depolymerization are essential for various cellular processes. BART1 associates with microtubules, and its proper function is contingent upon this interaction. Paclitaxel, a chemical inhibitor, stabilizes microtubules and prevents their disassembly, which affects the dynamics of microtubule-based processes that BART1 is involved in. Similarly, Eribulin exerts its inhibitory effect by halting the growth phase of microtubules without affecting the shortening phase, leading to a detrimental imbalance for BART1's activities. Both Colchicine and Vinblastine bind to tubulin and inhibit microtubule polymerization, which can disrupt BART1's interaction with the microtubule network. Vincristine also inhibits microtubule assembly by binding to tubulin, impeding processes necessary for BART1's correct functioning.
On the other hand, chemicals like Nocodazole and Podophyllotoxin act by interfering with the polymerization of tubulin, leading to the destabilization of microtubules and consequently inhibiting the function of BART1 associated with these structures. Albendazole, Mebendazole, Thiabendazole, and Parbendazole all disrupt microtubule formation by binding to tubulin, which is critical for the maintenance of the microtubule network that BART1 relies on. The disruption caused by these chemicals can inhibit BART1's functional interactions with microtubules. Griseofulvin, another chemical inhibitor, disrupts microtubule function through a similar mechanism, affecting the structural integrity of microtubules required for BART1's activity. Collectively, these chemical inhibitors can significantly inhibit BART1 by affecting the microtubule dynamics and structures that are crucial for its function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which can inhibit BART1 by disrupting the dynamics of microtubule-based processes that BART1 is involved in, particularly those related to its role in the trafficking and localization of proteins within cells. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting microtubule polymerization. Since BART1 associates with microtubules, this disruption can inhibit BART1's normal function by preventing its interaction with the microtubule network. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole interferes with microtubule polymerization. By destabilizing microtubules, it can inhibit BART1 function related to microtubule dynamics since BART1 is known to associate with microtubules for its proper functioning. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin, inhibiting microtubule formation. By preventing microtubule assembly, BART1 is inhibited from performing its role that requires interaction with a stable microtubule network. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits tubulin polymerization, leading to the breakdown of the microtubule network. BART1, which relies on intact microtubules for its activities, is inhibited as a result of the microtubule disruption. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase, leading to an imbalance that can inhibit BART1's microtubule-related functions. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by binding to tubulin, which can inhibit BART1 by affecting the microtubule structures necessary for its function. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $213.00 | 1 | |
Albendazole interferes with microtubule polymerization. As BART1 is involved in processes dependent on microtubules, the disruption caused by Albendazole can inhibit BART1's functional interactions with microtubules. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $46.00 $89.00 | 2 | |
Mebendazole disrupts microtubule formation by binding to tubulin. This inhibition of microtubule dynamics can inhibit BART1's function that is contingent on its association with microtubules. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Thiabendazole inhibits microtubule polymerization, which can inhibit BART1 by disrupting the microtubule network essential for its function. | ||||||