ATF-6β Inhibitors
ATF-6β inhibitors belong to a distinct chemical class characterized by their ability to modulate the activity of the activating transcription factor 6 beta (ATF-6β). ATF-6β is a crucial component of the unfolded protein response (UPR), an intracellular signaling pathway that acts to restore cellular homeostasis in the endoplasmic reticulum (ER) during periods of stress. The UPR is activated in response to the accumulation of unfolded or misfolded proteins in the ER, a condition known as ER stress. ATF-6β, a type II transmembrane protein residing in the ER membrane, serves as a key regulator in this process.
ATF-6β inhibitors are designed to interact with specific binding sites on ATF-6β, thereby modulating its function. The inhibition of ATF-6β is aimed at regulating the downstream transcriptional events that occur in response to ER stress, ultimately influencing the cellular fate in the face of proteotoxic stress. These inhibitors are carefully engineered compounds, often developed through medicinal chemistry approaches, with the primary goal of achieving selectivity for ATF-6β over other components of the UPR.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Guanabenz HCl | 23113-43-1 | sc-507500 | 100 mg | $246.00 | ||
An alpha-2 adrenergic receptor agonist that has been shown to attenuate ER stress and could modulate ATF6β activity indirectly through the UPR. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Inhibits dephosphorylation of eIF2α, leading to attenuation of ER stress and potentially modulating ATF6β activity as part of the UPR. | ||||||
ISRIB | 1597403-47-8 | sc-488404 | 10 mg | $300.00 | 1 | |
A small molecule that reverses the effects of eIF2α phosphorylation and can potentially modulate ATF6β activity by affecting the integrated stress response (ISR), which is connected to the UPR. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Known for its antimalarial activity, it can also inhibit autophagy and lysosomal degradation, leading to ER stress and potentially affecting ATF6β activity through the UPR. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
A glucose analog that inhibits glycolysis and can induce ER stress, thereby potentially modulating ATF6β activity as part of the UPR. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $73.00 $145.00 | ||
An inhibitor of glucosidases, can lead to ER stress by preventing proper folding of glycoproteins and potentially modulate ATF6β activity through the UPR. | ||||||