ATAD1 inhibitors belong to a specific category of chemical compounds that are designed to target and modulate the activity of the ATPase family AAA domain-containing protein 1 (ATAD1). ATAD1, also known as Thorase, is a member of the AAA+ (ATPases associated with various cellular activities) protein family, which plays a crucial role in various cellular processes. These inhibitors are meticulously crafted molecules that specifically interfere with the function of ATAD1, primarily by disrupting its ATPase activity. This inhibition can lead to a cascade of downstream effects within the cell, impacting processes such as protein trafficking, organelle dynamics, and quality control mechanisms.
The development and study of ATAD1 inhibitors have gained significant attention in recent years due to their potential implications in understanding fundamental cellular processes and their role in various diseases. Researchers have been working diligently to elucidate the precise mechanisms of action of these inhibitors, shedding light on the intricate web of cellular pathways regulated by ATAD1. By selectively targeting ATAD1, these inhibitors offer a valuable tool for studying the biological functions of this protein and its associated pathways, paving the way for a deeper understanding of cellular physiology. Additionally, ATAD1 inhibitors may hold promise for future applications in diseases where ATAD1 dysregulation is implicated, although this area of research is still in its early stages, and further investigation is needed to unlock their full potential.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
KU 60019 | 925701-46-8 | sc-363284 sc-363284A | 10 mg 50 mg | $248.00 $1035.00 | 1 | |
KU-60019 is a selective ATM kinase inhibitor, which may indirectly affect ATAD1 by interfering with cellular processes related to DNA damage responses. | ||||||
Tenovin-6 | 1011557-82-6 | sc-224296 sc-224296A | 1 mg 5 mg | $272.00 $1214.00 | 9 | |
Tenovin-6 primarily activates p53, but it may indirectly influence ATAD1 by impacting cellular processes interconnected with p53 functions. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin can modulate various cellular signaling pathways, which may impact ATAD1 functions indirectly, particularly those related to protein folding. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin affects cellular pathways, including those associated with protein degradation and interactions, which could indirectly influence ATAD1 function. | ||||||
Sunitinib Malate | 341031-54-7 | sc-220177 sc-220177A sc-220177B | 10 mg 100 mg 3 g | $197.00 $520.00 $1093.00 | 4 | |
Sunitinib primarily inhibits receptor tyrosine kinases, potentially affecting ATAD1 through interference with related cellular signaling pathways. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that can indirectly influence ATAD1 by blocking the degradation of ubiquitinated proteins, potentially affecting ATAD1 turnover. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin inhibits HSP90 and may indirectly inhibit ATAD1 by disrupting its association with HSP90, leading to degradation or misfolding. | ||||||
VER 155008 | 1134156-31-2 | sc-358808 sc-358808A | 10 mg 50 mg | $203.00 $842.00 | 9 | |
VER-155008 inhibits the heat shock response, potentially impacting ATAD1 since it is involved in protein quality control. | ||||||