AT1 Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
[Val5]-Angiotensin II acetate salt | 58-49-1 (non-salt) | sc-301966 | 5 mg | $106.00 | ||
[Val5]-Angiotensin II acetate salt exhibits unique molecular interactions, particularly through its capacity to form ionic bonds and engage in hydrophobic interactions. This compound influences cellular signaling pathways by modulating receptor affinity and activation kinetics. Its structural characteristics facilitate conformational changes upon binding, which can alter downstream effects in various biological systems. The acetate salt form enhances solubility, promoting its reactivity in diverse environments. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $50.00 $75.00 $260.00 $505.00 | 3 | |
Angiotensin II is a peptide that directly activates AT1 receptors. It binds to AT1 receptors, initiating a signaling cascade that involves G-protein coupling and activation of downstream pathways, ultimately leading to the activation of AT1 receptors. | ||||||
Losartan | 114798-26-4 | sc-353662 | 100 mg | $127.00 | 18 | |
Losartan is an angiotensin II receptor antagonist that indirectly activates AT1 receptors. By blocking the binding of endogenous angiotensin II to its receptor, losartan disrupts the negative feedback loop, resulting in increased expression and activation of AT1 receptors. | ||||||
Candesartan | 139481-59-7 | sc-217825 sc-217825B sc-217825A | 10 mg 100 mg 1 g | $46.00 $92.00 $148.00 | 6 | |
Candesartan is an angiotensin II receptor antagonist, similar to losartan, indirectly activating AT1 receptors by blocking the inhibitory effects of endogenous angiotensin II. This disruption of the negative feedback loop results in enhanced expression and activation of AT1 receptors. | ||||||
Olmesartan Medoxomil | 144689-63-4 | sc-219482 sc-219482A | 10 mg 100 mg | $60.00 $186.00 | ||
Olmesartan, another angiotensin II receptor antagonist, indirectly activates AT1 receptors by disrupting the inhibitory effects of endogenous angiotensin II. The consequent compensatory upregulation of AT1 receptors enhances their activation and downstream signaling pathways. | ||||||
Angiotensin fragment 1-7 acetate salt | 51833-78-4 | sc-319824 | 1 mg | $82.00 | 1 | |
Angiotensin II (1-7) is a metabolite of angiotensin II that can activate AT1 receptors. Despite its shorter sequence, it can bind to AT1 receptors, triggering signaling cascades similar to the full-length angiotensin II, leading to the activation of AT1 receptors. | ||||||
Valsartan | 137862-53-4 | sc-220362 sc-220362A sc-220362B | 10 mg 100 mg 1 g | $39.00 $90.00 $120.00 | 4 | |
EXP3174, also known as valsartan, is an angiotensin II receptor antagonist that indirectly activates AT1 receptors. Its mechanism is analogous to losartan and candesartan, disrupting the negative feedback loop associated with endogenous angiotensin II and promoting AT1 receptor activation. | ||||||
Aliskiren Hemifumarate | 173334-58-2 | sc-479906 | 1 mg | $490.00 | ||
Aliskiren is a direct renin inhibitor that indirectly activates AT1 receptors. By inhibiting renin activity, aliskiren disrupts the downstream production of angiotensin II, leading to compensatory upregulation and activation of AT1 receptors through increased availability of angiotensin II. | ||||||
Telmisartan | 144701-48-4 | sc-204907 sc-204907A | 50 mg 100 mg | $71.00 $92.00 | 8 | |
Telmisartan, an angiotensin II receptor antagonist, indirectly activates AT1 receptors by blocking the inhibitory effects of endogenous angiotensin II. This disruption of the negative feedback loop results in enhanced expression and activation of AT1 receptors, contributing to increased AT1 receptor activity. | ||||||
Irbesartan | 138402-11-6 | sc-218603 sc-218603A | 10 mg 50 mg | $104.00 $297.00 | 3 | |
Irbesartan, an angiotensin II receptor antagonist, indirectly activates AT1 receptors by disrupting the inhibitory effects of endogenous angiotensin II. This disruption of the negative feedback loop results in enhanced expression and activation of AT1 receptors, contributing to increased AT1 receptor activity. | ||||||