Asparagine synthetase Activators
The class of Asparagine synthetase (AS) activators encompasses a diverse array of molecules that either directly or indirectly influence the enzymatic activity of AS, a key player in cellular nitrogen metabolism. These activators play pivotal roles in modulating AS function, contributing to the finely tuned balance of asparagine synthesis within the cell. One group of activators includes amino acids such as glutamine, aspartic acid, and asparagine itself. Glutamine, a precursor to asparagine, serves as an indirect activator by enhancing substrate availability for AS, showcasing the interconnectedness of nitrogen metabolism. Aspartic acid contributes to the metabolic pathway leading to asparagine synthesis, indirectly influencing AS activity. Asparagine, acting as a feedback regulator, directly activates AS, creating a sophisticated feedback loop within the cellular nitrogen metabolism.
Beyond amino acids, compounds like cisplatin and mTORC1 activators exemplified by Rapamycin provide indirect activation of AS under specific cellular contexts. Cisplatin, a stress-inducing agent, can activate AS as part of the cellular stress response, demonstrating the enzyme's role in adaptive processes. mTORC1 activators, by influencing protein synthesis and cellular growth, indirectly impact AS activity, revealing connections between nutrient signaling and nitrogen metabolism regulation. Moreover, molecules like serine, glutathione, and S-Adenosyl methionine (SAM) participate in distinct cellular processes, such as one-carbon metabolism and redox homeostasis, indirectly influencing AS activity. These activators highlight the multifaceted regulatory networks that integrate AS into broader cellular functions. Notably, the class also includes nitrogen-rich amino acids mixtures and certain nitrogen-containing small molecules, emphasizing the versatility of molecules that can contribute to AS activation. These activators collectively contribute to the dynamic regulation of AS, reflecting the adaptability of cellular nitrogen metabolism to diverse physiological conditions. In summary, the class of AS activators represents a diverse and interconnected group of molecules that modulate AS activity through direct and indirect mechanisms. Understanding their roles expands our knowledge of the nuanced regulation of cellular nitrogen metabolism and the intricate balance maintained by AS within the cellular environment.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Glutamine | 56-85-9 | sc-391013 sc-391013C sc-391013A sc-391013D sc-391013B | 100 g 250 g 1 kg 5 kg 10 kg | $37.00 $47.00 $99.00 $379.00 $733.00 | 2 | |
Glutamine is an indirect activator of Asparagine synthetase (AS) by serving as a substrate. By providing an essential component for asparagine synthesis, glutamine indirectly modulates AS activity, influencing the enzyme's ability to convert aspartate to asparagine. Glutamine's role highlights the interconnectedness of cellular nitrogen metabolism and the regulation of AS. | ||||||
L-Glutamic Acid | 56-86-0 | sc-394004 sc-394004A | 10 g 100 g | $297.00 $577.00 | ||
Glutamic acid is an indirect activator of Asparagine synthetase (AS) by contributing to substrate availability. By participating in the metabolic pathway leading to asparagine synthesis, glutamic acid indirectly influences AS activity. This mechanism provides insights into the complex regulatory network governing cellular nitrogen metabolism and the role of AS in this intricate system. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin is an indirect activator of Asparagine synthetase (AS) through its impact on cellular stress response pathways. By inducing stress, cisplatin can potentially activate AS as part of the cell's adaptive response. Understanding the connection between cellular stress and AS activation provides insights into the broader regulatory networks governing AS function under different physiological conditions. | ||||||
L-Serine | 56-45-1 | sc-397670 sc-397670A sc-397670B sc-397670C sc-397670D | 1 g 100 g 1 kg 5 kg 10 kg | $20.00 $133.00 $546.00 $1224.00 $2040.00 | ||
Serine is an indirect activator of Asparagine synthetase (AS) by participating in the one-carbon metabolism pathway. As part of this pathway, serine indirectly influences AS activity, showcasing the intricate interplay between different metabolic pathways in the regulation of cellular nitrogen metabolism. Understanding how serine contributes to AS activation adds depth to our knowledge of the enzyme's multifaceted regulation. | ||||||
Glutathione, reduced | 70-18-8 | sc-29094 sc-29094A | 10 g 1 kg | $82.00 $2091.00 | 8 | |
Glutathione is an indirect activator of Asparagine synthetase (AS) through its involvement in redox homeostasis. By participating in cellular antioxidant mechanisms, glutathione indirectly influences AS activity. This connection between redox balance and AS activation provides insights into the broader regulatory networks that integrate cellular stress responses with nitrogen metabolism, highlighting the adaptability of AS function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTORC1 activators, exemplified by Rapamycin, can indirectly activate Asparagine synthetase (AS) through their influence on protein synthesis and cellular growth. As part of the mTORC1 signaling pathway, these activators impact AS activity, revealing a connection between nutrient signaling, protein synthesis, and the regulation of cellular nitrogen metabolism. Understanding this interplay expands our knowledge of AS regulation in dynamic cellular contexts. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
Ademetionine is an indirect activator of Asparagine synthetase (AS) through its involvement in methyl transfer reactions. By participating in cellular methylation processes, SAM indirectly influences AS activity, revealing a connection between epigenetic regulation and the modulation of nitrogen metabolism. Understanding how SAM impacts AS adds a layer of complexity to the enzyme's regulatory mechanisms. | ||||||