ASIC-β Activators
ASIC-β activators encompass a diverse range of chemical compounds that indirectly enhance the functional activity of ASIC-β through various biochemical pathways. Amiloride, by inhibiting ENaC channels, indirectly boosts ASIC-β activity due to their reciprocal regulatory relationship in neurons. The inhibition of ENaC alters sodium reabsorption, thereby facilitating increased sodium ion influx through ASIC-β. Similarly, Psoralen and Capsazepine, through their modulation of other ion channels, create changes in membrane potential and ion channel balance, indirectly augmenting ASIC-β activity. Capsazepine's antagonistic effect on TRPV1, for instance, can lead to a compensatory increase in ASIC-β activity. In addition, Verapamil and Bafilomycin A1 influence intracellular calcium levels and pH, respectively, both critical factors in regulating ASIC-β. Verapamil's reduction of calcium influx and Bafilomycin A1's elevation of intracellular pH enhance ASIC-β activity by altering the ion channel's regulatory mechanisms.
Continuing this interaction with intracellular processes, Ivermectin and Fenamates indirectly promote ASIC-β activity by modulating ionic balance and neuron excitability. The action of Ivermectin on various ion channels can lead to a conducive ionic environment for ASIC-β activation. Fenamates, by affecting other ion channels, particularly in sensory neurons, also contribute to enhanced ASIC-β activity. Furthermore, Ruthenium Red, Chlorpromazine, and Zinc impact ASIC-β through their modulation of calcium dynamics, membrane potential, and overall ionic balance. Ruthenium Red's inhibition of calcium channels, Chlorpromazine's influence on ion channel activity, and Zinc's effect on ionic balance all facilitate ASIC-β activation. Lastly, Quinine and Bisindolylmaleimide I, by altering the electrical properties of the membrane and intracellular signaling pathways, respectively, create a favorable condition for ASIC-β activation. Bisindolylmaleimide I, particularly, by inhibiting protein kinase C, impacts signaling pathways that regulate ASIC-β function, enhancing its activity. These diverse mechanisms collectively contribute to the enhanced functional activity of ASIC-β, demonstrating the intricate interplay of ion channel regulation and cellular signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amiloride | 2609-46-3 | sc-337527 | 1 g | $290.00 | 7 | |
Amiloride is a known blocker of epithelial sodium channels (ENaC). By inhibiting ENaC, it indirectly increases the activity of ASIC-β, as ENaC and ASIC-β have a reciprocal regulatory relationship in certain neurons and epithelial cells. The inhibition of ENaC reduces sodium reabsorption, which can indirectly enhance the sodium ion influx through ASIC-β. | ||||||
Psoralen | 66-97-7 | sc-205965 sc-205965A | 25 mg 100 mg | $101.00 $315.00 | 1 | |
Psoralen, a natural compound found in plants, is known to modulate various ion channels. Its interaction with other ion channels could lead to altered membrane potentials, which in turn can enhance ASIC-β activity, as ASIC-β is a proton-gated sodium channel sensitive to changes in membrane potential. | ||||||
Capsazepine | 138977-28-3 | sc-201098 sc-201098A | 5 mg 25 mg | $145.00 $450.00 | 11 | |
Capsazepine, a known TRPV1 antagonist, can indirectly affect ASIC-β. TRPV1 and ASIC-β channels co-localize in many sensory neurons. Inhibition of TRPV1 by Capsazepine can lead to a compensatory increase in ASIC-β activity, as both channels contribute to pain perception and sensory neuron excitability. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil, a calcium channel blocker, influences intracellular calcium levels. Reduced calcium influx can indirectly enhance ASIC-β activity by altering the calcium-dependent regulatory mechanisms that control ASIC-β, potentially leading to its increased activity in neurons. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $96.00 $250.00 $750.00 $1428.00 | 280 | |
Bafilomycin A1, a specific inhibitor of the V-ATPase proton pump, leads to increased intracellular pH. This pH alteration can enhance ASIC-β activity, as ASIC-β is a proton-sensitive channel, and its activity is modulated by intracellular pH levels. | ||||||
Ivermectin | 70288-86-7 | sc-203609 sc-203609A | 100 mg 1 g | $56.00 $75.00 | 2 | |
Ivermectin, an avermectin known for its antiparasitic properties, also affects various ion channels. It may indirectly enhance ASIC-β activity by modulating other ion channels and altering the ionic balance across the membrane, thereby influencing ASIC-β activation. | ||||||
Ruthenium red | 11103-72-3 | sc-202328 sc-202328A | 500 mg 1 g | $184.00 $245.00 | 13 | |
Ruthenium Red, an inhibitor of various calcium channels, can indirectly enhance ASIC-β activity by altering intracellular calcium dynamics, which in turn can influence the activity of calcium-sensitive ion channels like ASIC-β. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine, primarily an antipsychotic, also modulates ion channel activity. Its action on other ion channels could lead to membrane potential changes that enhance ASIC-β activity, as ASIC-β is sensitive to alterations in membrane potential. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc, an essential trace element, can modulate the activity of various ion channels. Increased zinc levels can indirectly enhance ASIC-β activity by affecting the overall ionic balance and membrane potential, which are critical factors for ASIC-β activation. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Quinine, known for its antimalarial properties, also influences ion channel activity. It could indirectly enhance ASIC-β activity by modulating other ion channels, thereby altering the electrical properties of the membrane where ASIC-β operates. | ||||||