ASB-7 Inhibitors
ASB-7 inhibitors act primarily through the ubiquitin-proteasome system, given that ASB-7 is an E3 ubiquitin ligase. Its main function is to mark proteins for degradation via the proteasome. Bortezomib, MG-132, Epoxomicin, and Lactacystin are proteasome inhibitors. They block the proteasome and thereby prevent the degradation of proteins ubiquitinated for destruction. ASB-7's function is indirectly inhibited due to the accumulation of proteins it has marked for destruction.
PYR-41 is an inhibitor of the ubiquitin-activating enzyme E1, which initiates ubiquitination. Without this initial step, ASB-7, being an E3 ubiquitin ligase, cannot mark proteins for degradation, leading to decreased functional activity. Similarly, MLN4924 inhibits the NEDD8 pathway involved in the modification of cullin proteins, which are an essential part of the Cullin-RING E3 ubiquitin ligases that ASB-7 belongs to. The functional activity of ASB-7 is disrupted by inhibiting the NEDD8 pathway. PR-619, a deubiquitinase inhibitor, disrupts the balance between ubiquitination and deubiquitination, which can inhibit ASB-7's function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor. ASB-7, as a member of the ASB family, is involved in the ubiquitin-proteasome pathway. Bortezomib blocks the degradation of proteins marked for destruction by ubiquitin, including those marked by ASB-7, leading to an accumulation of these proteins and thus functional inhibition of ASB-7. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132, like Bortezomib, is a proteasome inhibitor. It prevents the degradation of proteins marked for destruction by ubiquitin. This disrupts the balance between protein synthesis and degradation, which is a process ASB-7 is directly involved in, leading to a decrease in the functional activity of ASB-7. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
Epoxomicin is another proteasome inhibitor that blocks the degradation of proteins marked for destruction by ubiquitin. When the degradation process is disrupted by Epoxomicin, the function of ASB-7, which marks proteins for degradation, is indirectly inhibited. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
MLN4924 is a NEDD8-activating enzyme inhibitor. The NEDD8 pathway is involved in the modification of cullin proteins, which are part of the Cullin-RING E3 ubiquitin ligases that ASB-7 is a member of. Inhibiting the NEDD8 pathway can disrupt the function of ASB-7, leading to decreased activity. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
PYR-41 inhibits the ubiquitin-activating enzyme E1, which initiates ubiquitination. ASB-7, as an E3 ubiquitin ligase, cannot mark proteins for degradation without this initiation. Therefore, PYR-41 indirectly affects the function of ASB-7. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $75.00 $184.00 $423.00 | 1 | |
PR-619 is a broad-spectrum deubiquitinase inhibitor that disrupts the balance between ubiquitination and deubiquitination by inhibiting the removal of ubiquitin from proteins. This can inhibit the function of ASB-7, as this removal is a necessary step in the degradation of proteins marked by ASB-7. | ||||||
Eeyarestatin I | 412960-54-4 | sc-358130B sc-358130 sc-358130A sc-358130C sc-358130D sc-358130E | 5 mg 10 mg 25 mg 50 mg 100 mg 500 mg | $112.00 $199.00 $347.00 $683.00 $1336.00 $5722.00 | 12 | |
Eeyarestatin I inhibits the ER-associated degradation (ERAD) pathway. Inhibiting ERAD disrupts the balance between protein synthesis and degradation, thereby potentially inhibiting the function of ASB-7. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
Leupeptin is a protease inhibitor that can block the activity of various proteases. Inhibition of protease activity can disrupt the degradation of proteins marked by ASB-7, thus affecting its function. | ||||||