ART2A Inhibitors
ART2A inhibitors are a class of chemical compounds that specifically target and inhibit the enzymatic activity of ADP-ribosyltransferase 2A (ART2A), an enzyme involved in the post-translational modification process known as ADP-ribosylation. ART2A, like other members of the ADP-ribosyltransferase family, catalyzes the transfer of ADP-ribose from nicotinamide adenine dinucleotide (NAD⁺) to specific target proteins, often modifying arginine residues. This modification can regulate the function of proteins, including their stability, activity, and interactions with other cellular components. ART2A inhibitors interfere with this process by blocking the enzyme's ability to catalyze ADP-ribosylation, thereby preventing the modification of target proteins.
Inhibition of ART2A can have widespread effects on cellular signaling and protein function. By inhibiting the activity of ART2A, these compounds disrupt the addition of ADP-ribose units to specific protein substrates, potentially altering their structure, localization, or interactions within the cell. This can impact numerous cellular pathways, as ADP-ribosylation is a key regulator of processes such as signal transduction, protein-protein interactions, and cellular communication. ART2A inhibitors are valuable in research settings, where they are used to dissect the role of ADP-ribosylation in various biological processes. By selectively targeting ART2A, these inhibitors help to clarify the enzyme's role in modulating protein functions and provide a means to study the intricate regulatory mechanisms underlying ADP-ribosylation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide, a form of vitamin B3, may competitively inhibit NAD+ binding to ART2a, thus potentially leading to a downregulation of its enzymatic activity and subsequent decrease in gene expression as the cell tries to adjust to the reduced enzyme function. | ||||||
3-Aminobenzamide | 3544-24-9 | sc-3501 sc-3501B sc-3501A | 100 mg 1 g 5 g | $15.00 $36.00 $51.00 | 18 | |
By inhibiting poly(ADP-ribose) polymerases, 3-Aminobenzamide could indirectly decrease the ADP-ribosylation that is predicted to be facilitated by ART2a, potentially leading to a downregulation of ART2a expression as a secondary effect of disrupting this biochemical pathway. | ||||||
Isoniazid | 54-85-3 | sc-205722 sc-205722A sc-205722B | 5 g 50 g 100 g | $25.00 $99.00 $143.00 | ||
As a compound that alters NAD+ metabolism, Isoniazid may lead to a reduction in the availability of the cofactor necessary for ART2a's enzymatic activity, potentially triggering a decrease in ART2a expression to conserve cellular resources. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $37.00 $111.00 | 14 | |
Sirtinol may disrupt the cellular NAD+ levels, leading to a decrease in ART2a activity since it relies on NAD+ as a substrate. This disruption could signal the cell to downregulate ART2a expression in response to altered NAD+ homeostasis. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Theophylline could indirectly decrease the expression of ART2a by altering cellular cyclic AMP levels, which might reduce the transcriptional activity of genes involved in ADP-ribosylation processes. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate could reduce the proliferation of cells that express ART2a by inhibiting dihydrofolate reductase, leading to a reduction in the overall expression levels of ART2a in the affected cell populations. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound could decrease ART2a expression by causing hypomethylation of its gene promoter, thus reducing the transcription of the gene in cells where it is normally silenced by methylation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid could lead to the downregulation of ART2a expression by increasing histone acetylation and thereby altering the expression of various genes, including those involved in ADP-ribosylation. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin could decrease the expression of ART2a by intercalating into DNA and disrupting the transcription machinery, reducing the overall level of transcripts produced from the ART2a gene. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D may inhibit the transcription of ART2a directly by binding to its DNA sequence and preventing the transcriptional elongation by RNA polymerase. | ||||||