ARMC5 Activators
ARMC5 Activators can be classified into two primary groups. The first group is centered around modulators of the cAMP-PKA pathway. Chemicals like Forskolin, IBMX, Cilostamide, Rolipram, and Dibutyryl-cAMP function by increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can then phosphorylate various proteins and activate cellular pathways where ARMC5 plays a role. These activators provide a targeted approach to increase the expression or functionality of ARMC5 via the activation of the cAMP-PKA signaling axis.
The second group of activators includes ion channel modulators and kinase activators that act on diverse biochemical pathways. Anisomycin acts on the JNK pathway, while Genistein is a tyrosine kinase activator. A23187 and Ionomycin modulate calcium signaling, and PMA and OAG are activators of PKC. These chemicals act on unique cellular pathways that can interact with the functional domain of ARMC5 or its interacting partners. They can activate ARMC5 by either direct phosphorylation or activation of upstream signaling pathways, providing a multifaceted approach to ARMC5 activation.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Stimulates adenylate cyclase to raise cAMP levels, thereby activating PKA. PKA can phosphorylate proteins that may interact with ARMC5. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Inhibits phosphodiesterase, leading to elevated cAMP levels and activation of PKA. PKA can lead to activation of ARMC5 via phosphorylation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates Protein Kinase C (PKC), which can phosphorylate and activate interacting proteins that could subsequently activate ARMC5. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore that influences intracellular calcium signaling. This can lead to activation of pathways that may involve ARMC5. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Activates the JNK pathway, which can lead to the activation of proteins that may interact with ARMC5. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
A tyrosine kinase activator that can activate proteins or pathways potentially interacting with ARMC5. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium levels, which can activate signaling pathways possibly involving ARMC5. | ||||||
A-769662 | 844499-71-4 | sc-203790 sc-203790A sc-203790B sc-203790C sc-203790D | 10 mg 50 mg 100 mg 500 mg 1 g | $180.00 $726.00 $1055.00 $3350.00 $5200.00 | 23 | |
An AMPK activator that can regulate pathways leading to ARMC5 activation. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $90.00 $350.00 | 16 | |
Inhibits phosphodiesterase 3, elevating cAMP levels and PKA activation, which can activate pathways potentially leading to ARMC5 activation. | ||||||
1-Oleoyl-2-acetyl-sn-glycerol (OAG) | 86390-77-4 | sc-200417 sc-200417A | 10 mg 50 mg | $117.00 $444.00 | 1 | |
Activates PKC, which can interact with signaling proteins or pathways that may lead to the activation of ARMC5. | ||||||