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ARK-2 Inhibitors

ARK-2 inhibitors are a class of chemical compounds designed to inhibit the activity of the ARK-2 (Activated Receptor Kinase 2) enzyme, which plays a critical role in various cellular signaling pathways. ARK-2, a serine/threonine kinase, is involved in regulating several key processes, including cell cycle progression, apoptosis, and cellular response to stress. These inhibitors work by binding to the active site of ARK-2, preventing its phosphorylation activity. This binding typically occurs through interactions with the ATP-binding pocket of the enzyme, effectively blocking ATP access, which is crucial for the kinase's activity. The structure of ARK-2 inhibitors often includes a core scaffold that interacts with the hinge region of the kinase, along with additional substituents that enhance specificity and binding affinity. These compounds are generally designed through a combination of rational drug design and high-throughput screening, allowing for the identification of molecules with optimal inhibitory properties. The chemistry of ARK-2 inhibitors involves diverse structural motifs, with many compounds featuring heterocyclic cores such as pyridines, quinolines, or pyrimidines, which are known to interact favorably with kinase domains. These core structures are often modified with various functional groups, such as halogens, amides, or sulfonamides, to improve the pharmacokinetic and physicochemical properties of the inhibitors. Some ARK-2 inhibitors also incorporate hydrophobic moieties that enhance their ability to penetrate cell membranes, thus increasing their intracellular availability. The design of these inhibitors typically involves detailed structure-activity relationship (SAR) studies to optimize their selectivity towards ARK-2 while minimizing off-target effects. This selectivity is crucial as it ensures that the inhibitors specifically modulate ARK-2 activity without affecting other kinases, thereby providing a focused tool for studying the role of ARK-2 in various cellular processes. The development of ARK-2 inhibitors continues to be an active area of research, with ongoing efforts to refine their structural features and improve their binding efficacy.

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Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
4-Chloro-6,7-bis-(2-methoxy-ethoxy)-quinazoline	183322-18-1	sc-357724 sc-357724A	100 mg 250 mg	$131.00 $262.00		(0)
4-Chloro-6,7-bis-(2-methoxy-ethoxy)-quinazoline, as an ARK-2, demonstrates distinctive reactivity patterns that enable it to form transient complexes with key biomolecules. Its unique structure allows for enhanced solubility and permeability, facilitating rapid diffusion across cellular membranes. The compound's interactions with metal ions can alter its electronic properties, influencing reaction kinetics and enabling it to modulate specific biochemical pathways effectively.
PDGFR Tyrosine Kinase Inhibitor VI, SU6668	210644-62-5	sc-204175	5 mg	$79.00	9	(1)
PDGFR Tyrosine Kinase Inhibitor VI, known as SU6668, exhibits remarkable selectivity in targeting tyrosine kinase receptors, influencing cellular signaling cascades. Its unique molecular architecture promotes strong binding affinity, leading to the stabilization of enzyme-substrate complexes. This compound's ability to disrupt phosphorylation events alters downstream signaling, impacting cellular proliferation and differentiation. Additionally, its hydrophobic regions enhance interactions with lipid membranes, affecting cellular uptake dynamics.
OM137	292170-13-9	sc-255403	5 mg	$67.00		(0)
OM137, classified as an ARK-2, demonstrates intriguing reactivity as an acid halide, engaging in nucleophilic acyl substitution with remarkable efficiency. Its electrophilic carbonyl group facilitates rapid interactions with amines and alcohols, generating diverse acyl derivatives. The compound's unique steric configuration influences reaction kinetics, allowing for selective acylation pathways. Furthermore, its polar functional groups enhance solubility in various solvents, promoting versatile reactivity profiles in synthetic applications.
Paprotrain	57046-73-8	sc-364124A sc-364124	5 mg 10 mg	$90.00 $129.00	2	(1)
Paprotrain, an ARK-2 acid halide, exhibits distinctive reactivity characterized by its ability to form stable intermediates during nucleophilic acyl substitution. The compound's unique electronic properties enhance its electrophilicity, allowing for rapid and selective reactions with a range of nucleophiles. Additionally, its specific steric arrangement influences the regioselectivity of acylation, while its high reactivity in polar environments facilitates diverse synthetic transformations.
MLN 8054	869363-13-3	sc-484828	5 mg	$398.00		(0)
MLN8054 is an Aurora A kinase inhibitor that indirectly inhibits Aurora B, leading to cell cycle arrest. Its action on ARK-2 involves disrupting the formation of the mitotic spindle, which is crucial for cell division.
AT9283	896466-04-9	sc-364738 sc-364738A	2 mg 10 mg	$180.00 $400.00		(0)
AT9283 is a multi-targeted kinase inhibitor, including Aurora B, JAK2, and ABL kinases. By inhibiting ARK-2, it leads to cell cycle arrest and apoptosis, highlighting its role in chromosomal stability.

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ARK-2 Inhibitors

4-Chloro-6,7-bis-(2-methoxy-ethoxy)-quinazoline

PDGFR Tyrosine Kinase Inhibitor VI, SU6668

OM137

Paprotrain

MLN 8054

AT9283