ARH3 Activators
ARH3, also known as ADP-ribosylhydrolase 3, is an enzyme that plays a crucial role in cellular metabolism, particularly in the process of ADP-ribosylation. ADP-ribosylation is a post-translational modification where an ADP-ribose moiety is transferred to a target protein, affecting the protein's function. ARH3 is capable of hydrolyzing O-acetyl-ADP-ribose and poly(ADP-ribose), thereby reversing the modification of proteins.This enzymatic activity is particularly important in the context of DNA repair and cell stress responses. ADP-ribosylation is involved in the regulation of various cellular processes, including DNA repair, gene expression, and signaling pathways. The hydrolysis of ADP-ribose modifications by ARH3 is essential for maintaining the balance of protein function within the cell, allowing for the proper regulation of these processes.
ARH3 has been shown to have a significant impact on cellular response to DNA damage and is involved in the repair of single-strand breaks specifically. The enzyme's role in DNA repair mechanisms makes it a factor in maintaining genomic stability and protecting against diseases such as cancer, where DNA repair is often compromised.In addition to its role in DNA repair, ARH3 may also be involved in modulating cellular energy balance, cell death, and immune responses.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide, a form of vitamin B3, is a precursor of NAD+, a substrate for ADP-ribosylation reactions. It could indirectly affect the activity of ARH3 by influencing NAD+ levels. | ||||||
Sirtinol | 410536-97-9 | sc-205976 sc-205976A | 1 mg 5 mg | $38.00 $113.00 | 14 | |
Sirtinol is an inhibitor of sirtuin deacetylases, which are NAD+-dependent. It might indirectly influence ARH3 activity by modulating sirtuin activity and altering NAD+ dynamics. | ||||||
Veliparib | 912444-00-9 | sc-394457A sc-394457 sc-394457B | 5 mg 10 mg 50 mg | $182.00 $275.00 $726.00 | 3 | |
Veliparib is a PARP inhibitor that impedes DNA repair enzymes. It potentially impacts ADP-ribosylation processes, thus influencing ARH3 function. | ||||||
3-Aminobenzamide | 3544-24-9 | sc-3501 sc-3501B sc-3501A | 100 mg 1 g 5 g | $15.00 $37.00 $52.00 | 18 | |
3-Aminobenzamide is a PARP inhibitor that inhibits poly(ADP-ribose) synthesis and could influence ADP-ribosylation dynamics, potentially affecting ARH3 activity. | ||||||
PARP Inhibitor VIII, PJ34 | 344458-15-7 | sc-204161 sc-204161A | 1 mg 5 mg | $58.00 $142.00 | 20 | |
PJ34 is a potent PARP inhibitor that impacts ADP-ribosylation processes, potentially indirectly influencing ARH3 activity. | ||||||
Nicotinic Acid | 59-67-6 | sc-205768 sc-205768A | 250 g 500 g | $62.00 $124.00 | 1 | |
Niacin, a precursor to NAD+, could indirectly modulate ARH3 activity by influencing NAD+ biosynthesis. | ||||||
β-Nicotinamide mononucleotide | 1094-61-7 | sc-212376 sc-212376A sc-212376B sc-212376C sc-212376D | 25 mg 100 mg 1 g 2 g 5 g | $110.00 $150.00 $220.00 $300.00 $600.00 | 4 | |
NMN, a precursor to NAD+, could elevate cellular NAD+ levels, potentially affecting ADP-ribosylation processes and thereby influencing ARH3. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates sirtuins, NAD+-dependent deacetylases. This activation could indirectly influence NAD+ dynamics and ARH3 activity. | ||||||
Nicotinamide riboside | 1341-23-7 | sc-507345 | 10 mg | $411.00 | ||
Nicotinamide Riboside, a NAD+ precursor, increases cellular NAD+ levels, potentially influencing ARH3 activity by affecting substrate availability. | ||||||
Niraparib | 1038915-60-4 | sc-507492 | 10 mg | $150.00 | ||
Niraparib, a PARP inhibitor, influences DNA repair mechanisms, potentially impacting ARH3 and its related ADP-ribosylation activities. | ||||||