Apoptosis Repressor with CARD (ARC) Activators

Apoptosis Repressor with CARD (ARC) Activators, as the name suggests, are a class of compounds that can influence the activity of the ARC protein. While there are no direct chemical activators known for ARC, there are several chemicals that can indirectly impact its activity through associated signaling pathways. Among these chemicals, Phorbol Myristate Acetate (PMA) and Calcium Ionophore A23187 stand out. PMA can activate Protein Kinase C (PKC), which is closely tied to ARC-related pathways.

Calcium Ionophore A23187, on the other hand, modulates intracellular calcium levels, further influencing pathways where ARC has a role. Other notable compounds in this category include LY294002, PD98059, and Resveratrol. LY294002 inhibits the PI3K pathway, potentially influencing ARC's activity, while PD98059 acts on the ERK pathway, which is also associated with ARC. Resveratrol is versatile, affecting multiple pathways, some of which may be tied to ARC. This list is by no means exhaustive, but it gives insight into the wide array of chemicals that can indirectly influence ARC's activity through associated cellular processes and pathways.