Annexin A10 Activators
Annexin A10 Activators are a class of chemical compounds that can enhance the functional activity of Annexin A10, a protein that interacts with cellular phospholipids in a calcium-dependent manner. Forskolin and adenosine, known for their role in regulating intracellular cAMP levels, can indirectly increase the functional activity of Annexin A10. This is achieved by modulating calcium signaling, which plays a critical role in the phospholipid binding activity of Annexin A10. Similarly, Phorbol 12-myristate 13-acetate (PMA), a potent activator of protein kinase C (PKC), and Calyculin A, a protein phosphatase inhibitor, can influence the phosphorylation state of Annexin A10, potentially enhancing its functional activity.
In addition to these, bioactive lipids such as Eicosapentaenoic acid (EPA), Sphingosine 1-phosphate (S1P), and Lysophosphatidic acid (LPA) can modulate lipid rafts and lipid signaling, influencing the phospholipid binding activity of Annexin A10. Nitric Oxide (NO), known for its role in activating soluble guanylate cyclase and subsequently increasing intracellular cGMP levels, can indirectly modulate calcium signaling, thereby potentially enhancing the functional activity of Annexin A10. Finally, Histamine, Thrombin, and Prostaglandin E2 (PGE2), which can trigger increases in intracellular calcium levels, and Hypoxia-inducible factor 1-alpha (HIF-1α), which regulates the expression of genes involved in calcium signaling, can also enhance the phospholipid binding activity of Annexin A10.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a known activator of adenylyl cyclase, resulting in increased intracellular cAMP levels. Annexin A10 interacts with cellular phospholipids in a calcium-dependent manner, and cAMP can regulate calcium signaling. Therefore, forskolin can indirectly enhance the functional activity of Annexin A10. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which is involved in several signal transduction pathways. PKC can phosphorylate proteins, potentially influencing the calcium-dependent phospholipid binding activity of Annexin A10. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Calyculin A is a potent inhibitor of protein phosphatases. This can enhance the phosphorylation state of proteins, including Annexin A10, thereby potentially affecting its calcium-dependent phospholipid binding activity. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $102.00 $423.00 | ||
EPA is an omega-3 fatty acid that can modulate lipid rafts and lipid signaling. This can influence the calcium-dependent phospholipid binding activity of Annexin A10, thereby enhancing its functional activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P is a bioactive lipid that modulates lipid signaling and can influence the calcium-dependent phospholipid binding activity of Annexin A10, thereby enhancing its functional activity. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine is involved in the regulation of intracellular cAMP levels. By modulating cAMP and subsequent calcium signaling, adenosine can indirectly increase the functional activity of Annexin A10. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine can trigger increases in intracellular calcium levels. This can enhance the calcium-dependent phospholipid binding activity of Annexin A10. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $96.00 $334.00 | 50 | |
LPA is a bioactive lipid that can modulate lipid signaling and influence the phospholipid binding activity of Annexin A10, thereby enhancing its functional activity. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $230.00 | ||
Thrombin can trigger increases in intracellular calcium levels. This can enhance the calcium-dependent phospholipid binding activity of Annexin A10. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 can regulate calcium signaling, potentially enhancing the phospholipid binding activity of Annexin A10. | ||||||