ANKRD42 Activators
ANKRD42 encompass a range of compounds that initiate various signaling pathways, resulting in the modulation of the protein's activity. Forskolin acts directly on adenylyl cyclase to elevate intracellular levels of cAMP, which subsequently activates protein kinase A (PKA). The activated PKA can phosphorylate ANKRD42, leading to changes in its activity. Isoproterenol similarly increases cAMP levels through its action on beta-adrenergic receptors, providing another route for PKA-mediated phosphorylation of ANKRD42. Dibutyryl-cAMP, a cAMP analog, bypasses cell surface receptors and directly activates PKA, which could then target ANKRD42. Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which in turn may phosphorylate ANKRD42, altering its function. Bradykinin, through its receptor, sets off a cascade that also activates PKC, potentially influencing ANKRD42 activity via phosphorylation.
PIP3 serves as a docking site for proteins with pleckstrin homology (PH) domains, and if ANKRD42 or its interacting partners possess such domains, the presence of PIP3 could facilitate its activation by bringing it into proximity with other signaling molecules. Furthermore, the activation of the EGF receptor by Epidermal Growth Factor (EGF) can initiate a series of phosphorylation events through the MAPK/ERK pathway that may include ANKRD42. Insulin triggers its receptor to activate the PI3K/AKT pathway, which could lead to the phosphorylation of ANKRD42 or associated proteins, thus modulating ANKRD42's activity. Ionomycin, a calcium ionophore, raises intracellular calcium levels, potentially activating calcium-dependent protein kinases like PKC, which could then target ANKRD42. Calyculin A and Okadaic Acid, inhibitors of protein phosphatases PP1 and PP2A, prevent the dephosphorylation of proteins, which could result in a sustained activation state of ANKRD42. Anisomycin, by inhibiting protein synthesis, can activate stress-activated protein kinases such as JNK, which might then lead to the phosphorylation of ANKRD42 within stress response signaling pathways.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the insulin receptor, leading to the activation of the PI3K/AKT signaling pathway. AKT may then phosphorylate substrates that interact with or regulate ANKRD42 function, resulting in the activation of ANKRD42 through a cascade of phosphorylation events. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent protein kinases such as PKC. PKC may then phosphorylate and activate ANKRD42 if it is a substrate or if PKC activation leads to a signaling cascade that involves ANKRD42. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analogue that activates PKA. PKA can phosphorylate various proteins, potentially including ANKRD42 or proteins in pathways associated with ANKRD42, thereby leading to the functional activation of ANKRD42. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A), which prevents dephosphorylation of proteins. By inhibiting PP1 and PP2A, Calyculin A could lead to increased phosphorylation levels of proteins, including ANKRD42, thus maintaining ANKRD42 in an activated state. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is another inhibitor of PP1 and PP2A, similar to Calyculin A, resulting in increased phosphorylation and decreased dephosphorylation of proteins. This could lead to a sustained activation of ANKRD42 by preventing its deactivation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which may phosphorylate and activate ANKRD42 or initiate a signaling cascade involving ANKRD42, leading to its activation. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin activates its receptor which can lead to the activation of PLC, resulting in the generation of IP3 and DAG, second messengers that increase intracellular calcium and activate PKC, respectively. PKC activation may then lead to the phosphorylation and activation of ANKRD42. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that stimulates adenylyl cyclase, increasing cAMP levels which in turn activate PKA. PKA may phosphorylate ANKRD42 or proteins in pathways associated with ANKRD42, thus potentially leading to the activation of ANKRD42. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs) like JNK. JNK activation could lead to the phosphorylation and activation of ANKRD42 if it is involved in the stress response signaling pathways. | ||||||