alpha2A-AR Activators
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Items 1 to 10 of 17 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Xylometazoline hydrochloride | 1218-35-5 | sc-255719 | 5 g | $164.00 | ||
Xylometazoline hydrochloride interacts selectively with the alpha2A-adrenergic receptor, showcasing a unique binding profile characterized by electrostatic interactions and van der Waals forces. Its structural conformation allows for effective receptor modulation, influencing downstream signaling pathways. The compound exhibits notable stability in aqueous environments, with reaction kinetics indicating a rapid onset of action. Additionally, its lipophilic nature enhances its ability to traverse lipid membranes, impacting its bioavailability. | ||||||
Clonidine hydrochloride | 4205-91-8 | sc-203002 | 1 g | $367.00 | 12 | |
Clonidine hydrochloride exhibits a distinctive affinity for the alpha2A-adrenergic receptor, engaging in specific hydrogen bonding and hydrophobic interactions that facilitate receptor activation. Its unique stereochemistry contributes to a prolonged receptor engagement, influencing intracellular signaling cascades. The compound demonstrates a favorable solubility profile, allowing for efficient diffusion across biological membranes. Furthermore, its metabolic pathways reveal a complex interplay with enzymatic systems, affecting its pharmacokinetic behavior. | ||||||
Xylazine Hydrochloride | 23076-35-9 | sc-220393 | 1 g | $56.00 | 1 | |
Xylazine hydrochloride selectively binds to the alpha2A-adrenergic receptor, showcasing unique electrostatic interactions that enhance receptor affinity. Its structural conformation allows for effective allosteric modulation, influencing downstream signaling pathways. The compound's lipophilicity promotes rapid membrane permeability, while its metabolic degradation involves specific cytochrome P450 enzymes, leading to distinct kinetic profiles. This interplay of interactions underscores its complex biochemical behavior. | ||||||
Octopamine Hydrochloride | 770-05-8 | sc-203168 sc-203168A | 1 g 5 g | $51.00 $87.00 | ||
Octopamine hydrochloride exhibits a distinctive affinity for the alpha2A-adrenergic receptor, characterized by its ability to induce conformational changes that modulate receptor activity. Its unique amine structure facilitates hydrogen bonding, enhancing receptor-ligand interactions. The compound's hydrophilic nature influences solubility and distribution, while its metabolic pathway involves specific enzymatic transformations, contributing to its dynamic pharmacokinetic properties. This multifaceted behavior highlights its intricate biochemical interactions. | ||||||
Guanabenz acetate | 23256-50-0 | sc-203590 sc-203590A sc-203590B sc-203590C sc-203590D | 100 mg 500 mg 1 g 10 g 25 g | $100.00 $459.00 $816.00 $4080.00 $7140.00 | 2 | |
Direct agonist of α2A-AR, stimulating the receptor and initiating intracellular signaling cascades. | ||||||
Oxymetazoline Hydrochloride | 2315-02-8 | sc-203172B sc-203172 sc-203172C sc-203172A | 1 g 5 g 10 g 25 g | $93.00 $155.00 $360.00 $600.00 | 2 | |
Oxymetazoline Hydrochloride selectively engages with the alpha2A-adrenergic receptor, promoting a unique allosteric modulation that alters receptor signaling pathways. Its structural features enable specific ionic interactions, enhancing binding affinity and stability. The compound's lipophilic characteristics influence membrane permeability, while its metabolic profile reveals a series of enzymatic reactions that dictate its bioavailability and clearance. This intricate interplay underscores its complex biochemical behavior. | ||||||
Naphazoline Nitrate | 5144-52-5 | sc-205765 sc-205765A | 10 g 25 g | $59.00 $113.00 | ||
Naphazoline Nitrate exhibits a distinctive affinity for the alpha2A-adrenergic receptor, facilitating a nuanced modulation of neurotransmitter release. Its molecular architecture allows for specific hydrogen bonding and hydrophobic interactions, which enhance receptor activation. The compound's kinetic profile indicates rapid receptor engagement, followed by a gradual dissociation, influencing downstream signaling cascades. Additionally, its solubility characteristics affect distribution and interaction with biological membranes, highlighting its intricate biochemical dynamics. | ||||||
Guanfacine hydrochloride | 29110-48-3 | sc-203988 sc-203988A | 10 mg 50 mg | $66.00 $230.00 | ||
Guanfacine hydrochloride uniquely interacts with the alpha2A-adrenergic receptor, showcasing a selective binding affinity that influences presynaptic neurotransmitter release. Its structural conformation promotes effective electrostatic interactions and steric complementarity, enhancing receptor activation. The compound exhibits a moderate rate of receptor binding, leading to prolonged signaling effects. Furthermore, its solubility properties facilitate diverse interactions within lipid environments, underscoring its complex biochemical behavior. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Indirect activator that stimulates α2A-AR by acting as an endogenous ligand, binding to and activating the receptor. | ||||||
Medetomidine hydrochloride | 86347-15-1 | sc-204073 sc-204073A | 10 mg 50 mg | $121.00 $485.00 | 2 | |
Medetomidine hydrochloride exhibits a high specificity for the alpha2A-adrenergic receptor, engaging in unique hydrogen bonding and hydrophobic interactions that stabilize its binding. This compound modulates intracellular signaling pathways, particularly inhibiting adenylate cyclase activity, which results in decreased cyclic AMP levels. Its kinetic profile reveals a rapid onset of action, while its lipophilicity allows for effective membrane penetration, influencing its pharmacodynamics in various biological contexts. | ||||||