α T-catenin Activators
α T-catenin activators are a curated set of chemical compounds that indirectly enhance the functional activity of α T-catenin, each interacting with distinct cellular signaling pathways. Forskolin and IBMX, through their elevation of intracellular cAMP levels, indirectly promote α T-catenin's role in cell-cell adhesion by facilitating PKA activation, which may result in the phosphorylation of proteins within the cadherin-catenin complex, subsequently bolstering α T-catenin's adhesion function. Lithium Chloride and BIO contribute to this process by inhibiting GSK-3β, which normally phosphorylates and targets β-catenin for degradation; their action stabilizes β-catenin, possibly enhancing the integrity and function of α T-catenin within the adhesion complex.
Epigallocatechin Gallate (EGCG) and D4476, by inhibiting various kinases and CK1 respectively, may also contribute to the stabilization of cell-cell adhesion structures, indirectly promoting α T-catenin's adhesive functions. Lastly, Niclosamide, by altering cellular energy states, may create a cellular environment that favors the stabilization and activity of the cadherin-catenin complex, thereby supporting the functional activity of α T-catenin.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, which increases intracellular cAMP levels, leading to the activation of PKA. PKA can phosphorylate proteins involved in the cadherin-catenin complex, potentially enhancing α T-catenin's function in cell adhesion. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Isobutylmethylxanthine (IBMX) inhibits phosphodiesterases, preventing cAMP degradation, which supports PKA activity and may enhance α T-catenin's role in the cadherin-catenin complex by increased phosphorylation of associated proteins. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits GSK-3β, a kinase that can phosphorylate β-catenin leading to its degradation. Inhibition of GSK-3β stabilizes β-catenin, which can indirectly enhance α T-catenin's function by strengthening cadherin-catenin interactions. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
BIO is a specific GSK-3β inhibitor that prevents β-catenin phosphorylation and degradation, potentially enhancing α T-catenin's interaction with the cadherin-catenin complex by stabilizing β-catenin. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a broad kinase inhibitor that may stabilize cell-cell adhesion structures by reducing competitive signaling, which could indirectly enhance the functional role of α T-catenin in these complexes. | ||||||
Casein Kinase I Inhibitor, D4476 | 301836-43-1 | sc-202522 | 1 mg | $99.00 | 6 | |
D4476 is a CK1 inhibitor, and by inhibiting CK1, it might stabilize the cadherin-catenin complex, indirectly enhancing the functional role of α T-catenin in cell adhesion. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide uncouples mitochondrial oxidative phosphorylation, which can lead to alterations in cellular energy states and potentially enhance pathways that stabilize the cadherin-catenin complex, thus enhancing α T-catenin's activity. | ||||||