α3d Tubulin Inhibitors
α3d Tubulin Inhibitors represent a distinctive class of chemical compounds designed to modulate cellular processes by selectively targeting the α3 domain of tubulin, a critical component of the cytoskeleton. Tubulins are globular proteins that polymerize to form microtubules, dynamic structures essential for maintaining cell shape, intracellular transport, and chromosome segregation during cell division. The α3 domain, a specific region of tubulin, plays a pivotal role in regulating microtubule dynamics. α3d Tubulin Inhibitors exert their effects by binding selectively to this domain, thereby disrupting the normal assembly and disassembly of microtubules.
The mechanism of action of α3d Tubulin Inhibitors involves interference with microtubule dynamics, affecting processes such as mitosis and intracellular transport. By specifically targeting the α3 domain, these inhibitors induce conformational changes in tubulin that hinder its ability to polymerize into microtubules. As a result, cellular functions dependent on intact microtubule structures are perturbed. This class of compounds holds promise for elucidating the intricate details of tubulin regulation and microtubule dynamics within cells. Researchers are actively investigating the structure-activity relationships of α3d Tubulin Inhibitors to optimize their efficacy and selectivity. The exploration of this chemical class contributes to a deeper understanding of the complex mechanisms governing cellular architecture and provides valuable tools for probing the intricacies of cytoskeletal dynamics in various cellular contexts.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization into microtubules and potentially altering tubulin isotype expression. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics by binding to β-tubulin and may lead to changes in tubulin expression levels. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules, which can influence feedback mechanisms that regulate tubulin isotype expression. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine prevents tubulin polymerization into microtubules, which could impact tubulin isotype expression. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin binds to tubulin and disrupts its function, potentially altering tubulin expression patterns. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits tubulin polymerization, which could lead to changes in the expression of tubulin genes. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $46.00 $81.00 | ||
Combretastatin A-4 acts at the colchicine site on tubulin, inhibiting polymerization and potentially affecting expression. | ||||||
Mebendazole | 31431-39-7 | sc-204798 sc-204798A | 5 g 25 g | $46.00 $89.00 | 2 | |
Mebendazole targets β-tubulin and may affect the synthesis of tubulin, which could alter the expression of various isotypes. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $213.00 | 1 | |
Albendazole disrupts tubulin polymerization, which could influence the regulation of tubulin isotype expression. | ||||||
Thiabendazole | 148-79-8 | sc-204913 sc-204913A sc-204913B sc-204913C sc-204913D | 10 g 100 g 250 g 500 g 1 kg | $32.00 $84.00 $183.00 $312.00 $572.00 | 5 | |
Thiabendazole prevents microtubule assembly, potentially impacting the expression levels of tubulin isotypes. | ||||||