ALDH5A1 Activators
ALDH5A1 Activators encompass a diverse array of chemical compounds that indirectly contribute to the heightened functional activity of the enzyme ALDH5A1, which plays a pivotal role in the metabolism of aldehydes into acids, a vital biochemical process. Notably, the availability of NAD+ is crucial for ALDH5A1's catalytic action; hence, compounds such as NAD+ itself, Succinic acid, Alpha-ketoglutarate, and Malic acid, all intermediates or participants in the TCA cycle, serve to enhance the availability of NAD+, thereby promoting ALDH5A1's activity. Magnesium sulfate delivers essential magnesium ions to stabilize ALDH5A1's structure, augmenting its enzymatic efficiency. FAD and Riboflavin are intimately connected to the enzymatic reactions of ALDH5A1, with FAD acting as an electron acceptor to boost ALDH5A1's function and Riboflavin aiding the biosynthesis of FAD, thus indirectly enhancing ALDH5A1 activity through coenzyme contribution.
Further refining the cellular environment conducive to ALDH5A1's performance, other compounds such as Thiamine pyrophosphate and Lipoic acid ensure the provision and maintenance of necessary substrates and a reduced cellular state, respectively. S-adenosylmethionine (SAMe) influences the redox state of cellular metabolites, potentially optimizing conditions for ALDH5A1 functionality. Coenzyme Q10, participating in the mitochondrial electron transport chain, further ensures a steady regeneration of NAD+, thereby indirectly supporting the enzymatic efficiency of ALDH5A1. Collectively, these ALDH5A1 activators act through various biochemical pathways to fortify the enzyme's activity by ensuring the presence of necessary cofactors and maintaining a cellular environment that promotes ALDH5A1's catalytic processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a cofactor central to metabolism. ALDH5A1 relies on NAD+ for its aldehyde dehydrogenase activity. When NAD+ levels are high, ALDH5A1 activity can be enhanced as it catalyzes the oxidation of aldehydes to their corresponding acids. | ||||||
Magnesium sulfate anhydrous | 7487-88-9 | sc-211764 sc-211764A sc-211764B sc-211764C sc-211764D | 500 g 1 kg 2.5 kg 5 kg 10 kg | $46.00 $69.00 $163.00 $245.00 $418.00 | 3 | |
Magnesium acts as a cofactor for many enzymes, including ALDH5A1. Magnesium sulfate can provide the magnesium ions necessary to stabilize the structure of ALDH5A1 and enhance its catalytic activity. | ||||||
Thiamine pyrophosphate | 154-87-0 | sc-215966 sc-215966A sc-215966B sc-215966C sc-215966D | 1 g 5 g 25 g 100 g 1 kg | $33.00 $97.00 $290.00 $1149.00 $6024.00 | 1 | |
Thiamine pyrophosphate is a coenzyme for enzymes that catalyze the decarboxylation of alpha-keto acids. It supports the function of ALDH5A1 by ensuring the availability of substrates that ALDH5A1 can further metabolize. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Lipoic acid serves as a cofactor for mitochondrial enzymes and can enhance the antioxidant capacity of cells. By maintaining a reduced environment, lipoic acid can preserve the activity of ALDH5A1. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $45.00 $75.00 $133.00 | ||
Succinic acid is involved in the TCA cycle and can indirectly support ALDH5A1 by ensuring a continuous supply of NAD+, which is necessary for the enzymatic action of ALDH5A1. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
Alpha-ketoglutarate is an intermediate in the TCA cycle and can increase the availability of NAD+, indirectly enhancing ALDH5A1 activity by ensuring adequate cofactor availability. | ||||||
Ademetionine | 29908-03-0 | sc-278677 sc-278677A | 100 mg 1 g | $184.00 $668.00 | 2 | |
Ademetionine donates methyl groups in numerous methylation reactions and can affect the redox state of cellular metabolites, thereby potentially enhancing the functional state of ALDH5A1 indirectly. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $41.00 $112.00 $525.00 | 3 | |
Riboflavin is involved in the synthesis of FAD, a cofactor for ALDH5A1. By promoting FAD biosynthesis, riboflavin can potentiate the activity of ALDH5A1. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10 participates in the electron transport chain and maintains a reduced environment in mitochondria. It can indirectly enhance ALDH5A1 activity by ensuring the regeneration of NAD+ required for ALDH5A1 function. | ||||||
Malic acid | 6915-15-7 | sc-257687 | 100 g | $130.00 | 2 | |
Malic acid is a part of the TCA cycle and can increase the availability of NAD+, thereby indirectly enhancing the functional activity of ALDH5A1 by providing it with necessary cofactors for its reactions. | ||||||