AK4 Activators is a chemical class comprising compounds designed to stimulate or enhance the activity of Adenylate Kinase 4 (AK4), an enzyme intricately involved in cellular energy metabolism. These activators operate through various mechanisms that influence the adenine nucleotide pool within cells, specifically by promoting the conversion of adenosine triphosphate (ATP) to adenosine monophosphate (AMP). While AK4's precise physiological function remains under investigation, it is widely recognized for its significance in modulating the equilibrium of adenine nucleotides and, consequently, supporting essential cellular processes. AK4 activators, in essence, target this enzyme to maintain or improve energy homeostasis within the cell.
AK4 activators can be further categorized based on their respective modes of action. Some compounds may act by directly binding to AK4, altering its conformation, and enhancing its enzymatic activity. Others might indirectly impact AK4 by influencing cellular signaling pathways associated with energy metabolism. These activators are crucial tools in the realm of research and molecular biology, as they enable the study of AK4's regulatory role and its implications in cellular energy dynamics. Understanding AK4 activation mechanisms can potentially shed light on broader cellular processes and the intricate interplay of adenine nucleotide metabolism. Consequently, the development and characterization of AK4 activators continue to contribute to our understanding of cellular biochemistry, paving the way for innovative insights into metabolic regulation.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
Activates AMPK, which indirectly activates AK4 by modulating energy metabolism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Elevates cAMP levels, activating cellular signaling pathways that can indirectly activate AK4 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
A polyphenol known to activate mitochondrial function, potentially activating AK4 through energy-related mechanisms. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Modulates intracellular calcium levels, which can indirectly activate AK4 through calcium-dependent processes. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Inhibitor of PI3K and Akt kinases, impacting signaling pathways that indirectly activate AK4 activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Hormone that directly activates glucose metabolism, indirectly activating AK4 through energy-related pathways. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
Acts as an antioxidant, reducing ROS levels, which indirectly activates AK4 by mitigating oxidative stress-related processes. | ||||||
2,4-Dinitrophenol, wetted | 51-28-5 | sc-238345 | 250 mg | $58.00 | 2 | |
Uncouples oxidative phosphorylation from ATP synthesis, potentially activating AK4 through energy metabolism mechanisms. | ||||||
L-Thyroxine, free acid | 51-48-9 | sc-207813 sc-207813A | 100 mg 500 mg | $34.00 $73.00 | 2 | |
A thyroid hormone affecting cellular metabolism, which may indirectly activate AK4 by influencing energy-related processes. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $118.00 $320.00 $622.00 $928.00 $1234.00 | 38 | |
A PPARγ agonist that influences metabolism-related pathways, indirectly impacting AK4 activity by activating energy-related processes. |