ADAM34 Inhibitors
Chemical inhibitors of ADAM34 work through different mechanisms to inhibit the protease function of this protein. Marimastat and Batimastat are broad-spectrum metalloproteinase inhibitors that bind to the zinc-binding site within the metallopeptidase domain of ADAM34, which is essential for its proteolytic activity. By binding to this site, they prevent the cleavage of peptide bonds by ADAM34. Similarly, Ilomastat targets the same active site, preventing the proteolytic activity characteristic of ADAM34's domain. TAPI-0 also inhibits metalloproteinase activity by obstructing the access to the zinc-binding site, essential for the proteolytic function of ADAM34, leading to inhibition of its activity.
Other compounds like Doxycycline, which is traditionally known as an antibiotic, bind to the active sites of metalloproteinases, including ADAM34, inhibiting the interaction with its substrates and consequently its enzymatic activity. SB-3CT, while selective for MMP-2 and MMP-9, can inhibit ADAM34 by mimicking the substrate transition state, thereby blocking the active site. GM6001, or Galardin, is another broad-spectrum inhibitor that targets the zinc ion in the active site, blocking the enzymatic activity of ADAM34. PD 166793 and WAY-170523 work by binding to the metalloprotease domain of ADAM34, preventing the catalytic process essential for its function. Prinomastat occupies the zinc-binding site in the ADAM34 domain, which is crucial for the protein's activity. Ro 32-3555 is a selective inhibitor that binds to the active site of ADAM34, preventing the catalytic process and inhibiting its activity. Lastly, Andrographolide can inhibit ADAM34 by influencing NF-kB activation, which is involved in the regulation of metalloproteinase activity, potentially leading to reduced expression or activity of ADAM34.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Marimastat is a broad-spectrum metalloproteinase inhibitor that can inhibit ADAM34 by binding to its zinc-binding site, which is essential for the metallopeptidase domain's proteolytic activity. This binding prevents the cleavage of peptide bonds by ADAM34, leading to inhibition of its protease function. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Batimastat is another broad-spectrum metalloproteinase inhibitor that can inhibit ADAM34. It functions similarly to Marimastat by chelating the zinc ion in the active site of the metallopeptidase domain, which is crucial for the enzymatic activity of ADAM34, thus inhibiting its capacity to process substrates. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
Ilomastat, known as a matrix metalloproteinase inhibitor, can inhibit ADAM34 through its mechanism of binding to the active site containing zinc, preventing the proteolytic activity that is characteristic of the metallopeptidase domain of ADAM34. | ||||||
Doxycycline-d6 | 564-25-0 unlabeled | sc-218274 | 1 mg | $16500.00 | ||
Doxycycline, while an antibiotic, has been shown to inhibit metalloproteinases by binding to their active sites. This binding can inhibit ADAM34 by preventing the interaction of the protein's active site with its substrates, thereby inhibiting its enzymatic activity. | ||||||
SB-3CT | 292605-14-2 | sc-205847 sc-205847A | 1 mg 5 mg | $102.00 $388.00 | 15 | |
SB-3CT is a selective inhibitor of MMP-2 and MMP-9 but can inhibit ADAM34 by mimicking the substrate transition state, blocking the metalloproteinase domain's active site. This blockage inhibits ADAM34's protease function by preventing substrate cleavage. | ||||||
PD166793 | 199850-67-4 | sc-202709 | 5 mg | $150.00 | 6 | |
PD 166793 is a synthetic inhibitor of metalloproteinases that can inhibit ADAM34 by binding to its metalloprotease domain and obstructing the enzymatic activity necessary for its function, leading to inhibition of the protein's ability to process substrates. | ||||||
WAY 170523 | 307002-73-9 | sc-361402 sc-361402A | 1 mg 10 mg | $275.00 $595.00 | 1 | |
WAY-170523 is a potent and selective inhibitor of MMP-13 which can inhibit ADAM34 by binding to the active site of the metalloproteinase domain, preventing the proteolytic function of the protein and thus inhibiting its activity in substrate cleavage. | ||||||
Prinomastat | 192329-42-3 | sc-507449 | 5 mg | $190.00 | ||
Prinomastat is an inhibitor of matrix metalloproteinases that can inhibit ADAM34 by occupying its zinc-binding site, essential for the metallopeptidase domain's activity, leading to inhibition of the protein's ability to interact with and process its substrates. | ||||||
Ro 32-3555 | 190648-49-8 | sc-296277 | 10 mg | $413.00 | 2 | |
Ro 32-3555 is a selective metalloproteinase inhibitor that can inhibit ADAM34 by binding to its active site, preventing the catalytic process that is critical for its proteolytic function, thus inhibiting its activity. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Andrographolide, known for its anti-inflammatory properties, can inhibit ADAM34 indirectly by inhibiting NF-kB activation, which is a regulatory molecule in the signaling pathway of various metalloproteinases, potentially leading to inhibition of ADAM34 activity by reducing its expression or activity within this pathway. | ||||||