ACSM4 Activators
Acyl-CoA synthetase medium-chain family member 4 (ACSM4) play essential roles in the metabolic pathways that involve the conversion of fatty acids into their acyl-CoA derivatives. Acetyl-CoA, for instance, directly participates in the ACSM4 activity by providing the acetyl group necessary for the enzyme to carry out its function. This activation is further supported energetically by ATP, which supplies the required energy for the acyl-CoA synthetase reaction that ACSM4 catalyzes. Meanwhile, the presence of Coenzyme A is crucial as it accepts the fatty acid chain from ACSM4, forming the acyl-CoA product. Similarly, magnesium ions are vital cofactors that assist in the proper function of ACSM4 by stabilizing the ATP structure, thus enhancing the enzyme's activity.
ACSM4 is finely intertwined with several other metabolic components. L-Carnitine, for example, facilitates the transport of fatty acids into mitochondria, increasing the turnover rate of the acyl-CoA products that ACSM4 generates. This transport is pivotal for the subsequent β-oxidation processes. NAD+ and FAD are important cofactors in these oxidation reactions, which ensure the consumption of the acyl-CoA molecules produced by ACSM4, thereby indirectly sustaining the enzyme's activity. Moreover, molecules like nicotinamide and pantothenate contribute to the pool of necessary cofactors; nicotinamide is a precursor to NAD+, while pantothenate is involved in the biosynthesis of Coenzyme A. Biotin, although primarily a cofactor for carboxylase enzymes in fatty acid synthesis, can influence the availability of fatty acids for breakdown, thereby affecting ACSM4 activity. Lastly, alpha-lipoic acid, known for its role in energy metabolism within mitochondria, can enhance the demand for the acyl-CoA products, indirectly promoting the activation of ACSM4.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a coenzyme necessary for the dehydrogenase reactions in fatty acid oxidation, which ACSM4 supports by providing acyl-CoA substrates. The presence of NAD+ ensures the continuation of the β-oxidation pathway where ACSM4's products are utilized, thereby indirectly supporting the activation of ACSM4's enzymatic function. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
L-Carnitine facilitates the transport of fatty acids into the mitochondria for β-oxidation, where ACSM4’s products are utilized. The increased transport of fatty acids may indirectly activate ACSM4 by increasing the turnover rate of its acyl-CoA products, leading to enhanced ACSM4 activity. | ||||||
Coenzyme A | 85-61-0 anhydrous | sc-211123 sc-211123A sc-211123B sc-211123C | 10 mg 25 mg 100 mg 250 mg | $83.00 $135.00 $418.00 $801.00 | 1 | |
Coenzyme A is required for the acyl-CoA synthetase reaction catalyzed by ACSM4. By providing the CoA moiety, it directly activates ACSM4 function by enabling the conversion of fatty acids to their corresponding acyl-CoA derivatives, which are then available for subsequent metabolic pathways. | ||||||
ADP | 58-64-0 | sc-507362 | 5 g | $54.00 | ||
ATP provides the energy necessary for the acyl-CoA synthetase reaction of ACSM4, thereby directly activating the enzyme's function. This reaction is critical for the conversion of fatty acids into their acyl-CoA forms, which are essential for their subsequent metabolism in β-oxidation. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Nicotinamide is a form of vitamin B3 and a precursor to NAD+, which is a cofactor for dehydrogenase enzymes in fatty acid oxidation. By contributing to the pool of NAD+, nicotinamide indirectly activates ACSM4 by supporting the metabolic pathway in which the enzyme's products are utilized. | ||||||
D-(+)-Biotin | 58-85-5 | sc-204706 sc-204706A sc-204706B | 1 g 5 g 25 g | $41.00 $107.00 $333.00 | 1 | |
Biotin acts as a cofactor for carboxylase enzymes, which are involved in fatty acid synthesis. While this process is seemingly opposite to ACSM4's function, the regulation of fatty acid synthesis and breakdown is interrelated; thus, biotin can indirectly activate ACSM4 by modulating the pool of fatty acids available for metabolism. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid is an antioxidant that is also involved in mitochondrial energy metabolism. It can indirectly activate ACSM4 by improving mitochondrial function and efficiency, possibly increasing the demand for acyl-CoA products generated by ACSM4 for energy productionIt seems you have requested a table containing information about chemical substances and how they relate to ACSM4 activity. Below is a formatted representation of the information: | ||||||