ACADSB Activators
ACADSB Activators encompass a series of compounds that, through various mechanisms, enhance the functional activity of ACADSB, a protein critical in the beta-oxidation of short- to medium-chain fatty acids within mitochondria. L-Carnitine, for instance, optimizes fatty acid transport into the mitochondria, directly correlating with increased substrate availability for ACADSB-mediated metabolism. Similarly, the presence of adequate Riboflavin ensures the availability of FAD, a necessary cofactor for ACADSB, thus facilitating its catalytic actions. Bezafibrate and PPAR-delta agonists like GW501516 amplify the expression of genes associated with fatty acid oxidation, thereby indirectly augmenting the functional environment for ACADSB's activity. These mechanisms indicate that the activity of ACADSB is tightly regulated by the availability of substrate as well as the presence of necessary coenzymes and cofactors, which are influenced by these activators.
Moreover, compounds such as Nicotinamide adenine dinucleotide (NAD+) and Alpha-lipoic acid serve to maintain the mitochondrial health and metabolic efficiency, which is a pre-requisite for the optimal functioning of ACADSB. Coenzyme Q10 further supports this by contributing to a robust electron transport chain, ensuring an efficient energy supply for metabolic processes, including those involving ACADSB. Fibrates like Gemfibrozil potentiate ACADSB's role by enhancing fatty acid metabolism via PPAR-alpha activation. Additionally, the indirect influence of Magnesium and Vitamin B12 on the metabolic pathways underscores the complex interplay of nutrients and metabolic enhancers in modulating the activity of ACADSB, demonstrating the multifaceted approach to optimizing its function in cellular metabolism.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
L-Carnitine facilitates the transport of fatty acids into the mitochondria for beta-oxidation. By increasing the availability of fatty acid substrates, L-Carnitine indirectly enhances the functional activity of ACADSB in fatty acid metabolism. | ||||||
Riboflavin | 83-88-5 | sc-205906 sc-205906A sc-205906B | 25 g 100 g 1 kg | $41.00 $112.00 $525.00 | 3 | |
Riboflavin is a precursor for FAD, a cofactor for ACADSB. An increase in riboflavin intake can lead to higher FAD levels, which could enhance ACADSB activity by ensuring adequate cofactor availability for fatty acid oxidation processes. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
Bezafibrate activates peroxisome proliferator-activated receptors (PPARs) which upregulate the expression of genes involved in fatty acid oxidation, including ACADSB. This can indirectly increase ACADSB activity by enhancing its functional environment. | ||||||
Ob (hBA-147) | sc-4912 | 1000 µg | $258.00 | 1 | ||
Ob (hBA-147) has been found to upregulate fatty acid oxidation. While it is a protein, synthetic small-molecule mimetics of leptin can potentially enhance ACADSB activity indirectly by upregulating the metabolic pathways that include ACADSB. | ||||||
GW501516 | 317318-70-0 | sc-202642 sc-202642A | 1 mg 5 mg | $82.00 $179.00 | 28 | |
GW501516 is a potent PPAR-delta agonist that stimulates the expression of genes involved in fatty acid oxidation, potentially increasing ACADSB activity by enhancing the utilization of its substrates in the metabolism. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is an essential cofactor for many dehydrogenases, including ACADSB. Supplementation with NAD+ precursors could support enhanced ACADSB activity by maintaining optimal cofactor levels for fatty acid oxidation reactions. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Alpha-lipoic acid is known to induce mitochondrial biogenesis and support enzymes involved in metabolic pathways, including fatty acid oxidation where ACADSB is active, potentially enhancing its function indirectly by improving mitochondrial function. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Coenzyme Q10 is involved in the electron transport chain and could support ACADSB activity indirectly by maintaining an optimal oxidative environment for fatty acid metabolism within the mitochondria. | ||||||
Gemfibrozil | 25812-30-0 | sc-204764 sc-204764A | 5 g 25 g | $66.00 $267.00 | 2 | |
Gemfibrozil, a fibrate drug, activates PPAR-alpha which can enhance the catabolism of fatty acids and potentially increase the activity of ACADSB indirectly by increasing the demand for fatty acid oxidation. | ||||||
Vitamin B12 | 68-19-9 | sc-296695 sc-296695A sc-296695B sc-296695C sc-296695D sc-296695E | 100 mg 1 g 5 g 25 g 100 g 1 kg | $60.00 $90.00 $325.00 $1155.00 $3851.00 $10056.00 | 2 | |
Vitamin B12 is essential for proper fatty acid metabolism and could indirectly support ACADSB function by facilitating overall metabolism, including the catabolism of fatty acids where ACADSB is involved. | ||||||