ABHD1 Inhibitors
ABHD1 inhibitors may contain compounds such as betulinic acid and soraphen A alter the synthesis and turnover of fatty acids, thus indirectly affecting ABHD1 by modifying the pool of lipid substrates and intermediates within the cell. Triacsin C and statins like simvastatin work by inhibiting enzymes that are critical for lipid activation and cholesterol synthesis, respectively, leading to changes in lipid composition and potentially modulating ABHD1 activity.
Compounds that affect nuclear receptors involved in lipid metabolism, such as thiazolidinediones, oleoylethanolamide, GW9662, medica 16, and fenofibrate, can cause broad changes in the expression of genes involved in lipid handling and metabolism, which can subsequently influence ABHD1 activity. These compounds operate through PPAR receptors, which are transcription factors that play a significant role in regulating lipid metabolism. Curcumin and capsaicin, on the other hand, exert their influence by modulating signaling pathways and cellular mechanisms that can lead to an altered metabolic state within the cell, which can then impact the activity of ABHD1. Nicotinamide, through its function as a vitamin B3 derivative, can affect cellular metabolism and redox reactions, thereby influencing lipid metabolism and ABHD1 indirectly.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Inhibits topoisomerase, which can lead to reduced cell proliferation and altered lipid metabolism, thus indirectly influencing ABHD1. | ||||||
Triacsin C Solution in DMSO | 76896-80-5 | sc-200574 sc-200574A | 100 µg 1 mg | $187.00 $843.00 | 14 | |
Inhibits long-chain acyl-CoA synthetase, diminishing fatty acid activation and can indirectly decrease ABHD1's substrate availability. | ||||||
2,4-Thiazolidinedione | 2295-31-0 | sc-216281 | 50 g | $177.00 | 3 | |
Activate PPARγ, a nuclear receptor that regulates fatty acid storage and glucose metabolism, which can influence ABHD1 indirectly by altering lipid signaling. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates various signaling pathways including inflammation and oxidative stress, which can affect ABHD1 activity indirectly by altering cellular lipid metabolism. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Activates TRPV1 channels influencing cellular calcium levels and metabolism, which can indirectly affect ABHD1 activity through metabolic changes. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
An HMG-CoA reductase inhibitor, decreases cholesterol synthesis which can lead to alterations in cellular lipid profiles and indirectly influence ABHD1. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
As an NAD+ precursor, can modulate cellular metabolism and thus indirectly influence ABHD1 through changes in cellular redox states and lipid metabolism. | ||||||
Oleylethanolamide | 111-58-0 | sc-201400 sc-201400A | 10 mg 50 mg | $90.00 $194.00 | 1 | |
An endogenous PPARα agonist, can modulate lipid metabolism pathways, thereby indirectly affecting ABHD1 activity. | ||||||
GW 9662 | 22978-25-2 | sc-202641 | 5 mg | $70.00 | 30 | |
Irreversible PPARγ antagonist, can alter lipid metabolism and thus have an indirect effect on ABHD1 activity. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Another PPARα agonist, can also modulate lipid metabolism, potentially affecting ABHD1 activity indirectly. | ||||||