Abcg3 Activators

Chemical activators of ATP binding cassette subfamily G member 3 engage with various cellular pathways to modulate the activity of this protein. 4-Phenylbutyrate exerts its effects through histone deacetylase inhibition, which leads to enhanced acetylation of proteins, thus affecting their stability and function, resulting in increased activity of ATP binding cassette subfamily G member 3. Similarly, sulfasalazine works by inhibiting the factor NF-kB, which regulates the expression of certain transporters, including ATP binding cassette subfamily G member 3, leading to its activation by diminishing repression. GW4064, a synthetic FXR agonist, activates the farnesoid X receptor, which then upregulates the expression and activity of ATP binding cassette subfamily G member 3 via the FXR-mediated transcriptional pathway. T0901317, targeting the liver X receptor, and chenodeoxycholic acid, an endogenous FXR ligand, both facilitate the activation of ATP binding cassette subfamily G member 3 through similar receptor-dependent signaling pathways, enhancing the transcription of genes that are critical for lipid metabolism and transport.

Further, pregnenolone 16α-carbonitrile induces the pregnane X receptor, which subsequently increases the expression of genes involved in xenobiotic metabolism, leading to the activation of ATP binding cassette subfamily G member 3. Pioglitazone, by activating PPAR-gamma, and oleanolic acid, activating the PPAR signaling pathway, both contribute to the modulation of gene transcription encoding ABC transporters, thereby facilitating the activity of ATP binding cassette subfamily G member 3. Rifampicin, a potent inducer of PXR, and dexamethasone, through glucocorticoid receptor-mediated signaling, both promote the activation of ATP binding cassette subfamily G member 3 by influencing the expression and activity of various ABC transporters. Additionally, natural compounds like chrysin and curcumin engage with PPAR-mediated and NF-kB pathways, respectively, leading to the regulation of ATP binding cassette subfamily G member 3 activity and expression by modulating the transcription and activity of ABC transporters.