AACT Activators
The chemical class known as AACT Activators encompasses a group of compounds that can modulate the expression and activity of Alpha-1-Antichymotrypsin (AACT), also referred to as SERPINA3. AACT is a glycoprotein primarily synthesized in the liver and is known to play a role in inhibiting serine proteases, particularly chymotrypsin-like enzymes. AACT activators work through various mechanisms to influence the production and function of AACT within cells. One of the key mechanisms through which AACT activators exert their effects is by directly interacting with cellular components that regulate AACT gene expression. For instance, chemicals like Trichostatin A (TSA) and Valproic Acid function as histone deacetylase inhibitors, which enhance histone acetylation at the SERPINA3 gene locus. This epigenetic modification results in a more permissive chromatin structure, allowing for increased gene transcription and subsequently elevated AACT levels.
Furthermore, several AACT activators, such as 5-Azacytidine and Decitabine, function as DNA demethylating agents. These compounds indirectly activate AACT by reducing DNA methylation at the SERPINA3 promoter region, making the gene more accessible for transcription. DMSO (Dimethyl Sulfoxide) can also induce AACT expression by serving as a solvent for specific AACT-activating compounds, thus facilitating their cellular uptake and bioavailability.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol can activate AACT by binding to specific receptors or cellular signaling pathways that promote the transcription and translation of the SERPINA3 gene, ultimately increasing AACT production. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This DNA demethylating agent indirectly activates AACT by reducing DNA methylation at the SERPINA3 promoter region, making it more accessible for transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
TSA, a histone deacetylase inhibitor, promotes AACT expression by increasing histone acetylation at the SERPINA3 gene locus, facilitating transcription. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO can induce AACT expression by acting as a solvent for certain AACT-activating compounds, making them more accessible within the cell. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid, another histone deacetylase inhibitor, promotes AACT expression by enhancing histone acetylation levels at the SERPINA3 gene locus, facilitating transcription. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
This demethylating agent activates AACT by reducing DNA methylation at the SERPINA3 promoter, leading to increased gene expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid (Vorinostat), an HDAC inhibitor, can promote AACT expression by increasing histone acetylation levels, facilitating gene transcription. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $64.00 $177.00 | ||
Butyric acid indirectly activates AACT expression by serving as a precursor to histone acetylation in the cell, leading to increased histone acetylation levels and enhanced transcription. | ||||||