A430084P05Rik Activators
Chemical activators of SLP adaptor and CSK interacting membrane protein play a pivotal role in the modulation of intracellular signaling pathways. Phorbol 12-myristate 13-acetate (PMA) is one such activator, functioning by stimulating protein kinase C (PKC), which subsequently phosphorylates various substrates that can interact with and activate the SLP adaptor and CSK interacting membrane protein. Similarly, bryostatin 1 and mezerein also act as activators of PKC, leading to the activation of the same protein through the phosphorylation cascade. Ingenol and teleocidin contribute to the activation process in an analogous manner, promoting the PKC pathway and subsequent phosphorylation events. These activators ensure the phosphorylation of specific proteins that interact with the SLP adaptor and CSK interacting membrane protein, ensuring its activation.
Additionally, ionomycin raises intracellular calcium levels, which activates calcium-dependent signaling pathways that can also result in the activation of SLP adaptor and CSK interacting membrane protein. Thapsigargin achieves a similar effect by inhibiting the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels and the activation of calcium-mediated signaling pathways. Alongside these, forskolin and dibutyryl-cAMP elevate intracellular cAMP, activating protein kinase A (PKA) that phosphorylates various targets, including those associated with the SLP adaptor and CSK interacting membrane protein. Okadaic acid and calyculin A inhibit protein phosphatases 1 and 2A, leading to an increase in phosphorylation levels of proteins within the cell, which promotes the activation of SLP adaptor and CSK interacting membrane protein. Anisomycin activates the JNK signaling pathway, resulting in the activation of transcription factors and regulatory proteins that interact with the SLP adaptor and CSK interacting membrane protein, facilitating its activation through a distinct signaling pathway. These diverse chemicals, by different mechanisms, ensure the phosphorylation and activation of the SLP adaptor and CSK interacting membrane protein, each contributing to the regulation of complex cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in the signaling pathways that lead to the activation of SLP adaptor and CSK interacting membrane protein by phosphorylating downstream molecules that can interact with and activate this protein. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, which can activate calcium-sensitive signaling pathways, resulting in the activation of SLP adaptor and CSK interacting membrane protein through the phosphorylation of associated signaling proteins. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that activates PKA, which can then phosphorylate proteins in the signaling cascade that are involved in the activation of SLP adaptor and CSK interacting membrane protein. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 acts as a PKC activator, which can lead to the activation of signaling pathways involving SLP adaptor and CSK interacting membrane protein, ultimately resulting in its functional activation through phosphorylation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels within cells, which can contribute to the activation of SLP adaptor and CSK interacting membrane protein through enhanced phosphorylation signaling. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A also inhibits protein phosphatases, particularly PP1 and PP2A, which can indirectly lead to the phosphorylation and activation of proteins in the signaling pathway that includes SLP adaptor and CSK interacting membrane protein. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Teleocidin is a PKC activator. By promoting PKC-mediated signaling pathways, it can contribute to the phosphorylation and consequent activation of SLP adaptor and CSK interacting membrane protein. | ||||||
Ingenol | 30220-46-3 | sc-202184 sc-202184A sc-202184B sc-202184C | 1 mg 5 mg 10 mg 25 mg | $69.00 $305.00 $446.00 $1120.00 | 1 | |
Ingenol is an activator of PKC which, through the phosphorylation of downstream signaling molecules, can result in the activation of SLP adaptor and CSK interacting membrane protein. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels, which activates calcium-dependent signaling pathways that could lead to the activation of SLP adaptor and CSK interacting membrane protein. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a JNK activator that can stimulate the JNK signaling pathway, resulting in the activation of transcription factors and regulatory proteins that interact with and promote the activation of SLP adaptor and CSK interacting membrane protein. | ||||||