9830001H06Rik Activators
Chemical activators of microtubule crosslinking factor 2 can function by either promoting the polymerization and stabilization of microtubules or by disrupting microtubule dynamics, leading to compensatory mechanisms that activate the protein. Paclitaxel, Taxol, Epothilone B, Peloruside A, and Laulimalide all share a common mechanism of action in that they stabilize microtubules. This stabilization can enhance the activation of microtubule crosslinking factor 2 by maintaining the microtubules in a polymerized state, which is a favorable condition for the crosslinking function of the protein. The stabilized microtubules provide a scaffold that facilitates the crosslinking action, thereby promoting the activation of microtubule crosslinking factor 2. These chemicals ensure that the microtubules remain in a state that supports the structural integrity of the cellular cytoskeleton.
Conversely, chemicals like Nocodazole, Colchicine, Vinblastine, Vincristine, Griseofulvin, Podophyllotoxin, and Combretastatin A-4 disrupt microtubule function by either depolymerizing the microtubules or inhibiting their polymerization. This disruption can lead to the activation of microtubule crosslinking factor 2 as part of the cellular response to maintain cytoskeletal structure. The cell may increase the activation of crosslinking proteins to counteract the destabilizing effects of these agents. The disruption caused by these chemicals creates a cellular environment that necessitates the activation of microtubule crosslinking factor 2 to reinforce and stabilize the microtubule network, ensuring the preservation of cellular architecture and function despite the challenges to microtubule integrity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and can activate microtubule crosslinking factor 2 by promoting microtubule polymerization and stability, which is a necessary condition for the crosslinking activity of the protein. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics, leading to microtubule depolymerization. This can activate microtubule crosslinking factor 2 by triggering compensatory mechanisms in the cell to stabilize and crosslink microtubules as a response to maintain cellular structure. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin, preventing its polymerization. This can activate microtubule crosslinking factor 2 indirectly, as the cell may increase the activation of crosslinking proteins to counteract the destabilization of microtubules caused by colchicine. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine interferes with microtubule assembly. The activation of microtubule crosslinking factor 2 may occur as a cellular response to maintain microtubule integrity when challenged with vinblastine. | ||||||
Epothilone B, Synthetic | 152044-54-7 | sc-203944 | 2 mg | $176.00 | ||
Epothilone B functions similarly to paclitaxel by stabilizing microtubules, thereby providing a favorable environment for the activation of microtubule crosslinking factor 2 as it promotes crosslinking to maintain microtubule structure. | ||||||
Laulimalide | 115268-43-4 | sc-507261 | 100 µg | $200.00 | ||
Laulimalide promotes microtubule polymerization and can activate microtubule crosslinking factor 2 by enhancing microtubule stability, which is necessary for the crosslinking function of the protein. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin disrupts microtubule function by interacting with tubulin. This can activate microtubule crosslinking factor 2 as a part of the cellular response to counteract the destabilization and support the microtubule network. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin binds to tubulin and inhibits its polymerization. This can activate microtubule crosslinking factor 2 as the cell compensates for the loss of microtubule integrity by potentially increasing the activity of crosslinking proteins. | ||||||